Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
2.9
Journals
JCM
Special Issues
Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality...
jcm-logo
Submit to Special Issue Submit Abstract to Special Issue Review for JCM Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 21 August 2026 | Viewed by 1928

Special Issue Editors

Dr. Gloria Roberti

E-Mail Website
Guest Editor
IRCCS—Fondazione Bietti, Via Livenza, 3, 00198 Rome, Italy
Interests: glaucoma; cataract; visual field; medical treatment; surgical treatment
Special Issues, Collections and Topics in MDPI journals
Dr. Manuele Michelessi

E-Mail Website
Guest Editor
IRCCS—Fondazione Bietti, Via Livenza, 3, 00198 Rome, Italy
Interests: glaucoma; ocular surface; medical treatment; surgical treatment; in vivo confocal microscopy; anterior segment optical coherence tomography
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Glaucoma surgery continues to evolve with the goal of preserving vision, preventing disease progression, and improving patient quality of life. This Special Issue focuses on the clinical outcomes of both traditional and modern glaucoma procedures, including trabeculectomy, bleb-forming devices, minimally invasive glaucoma surgery (MIGS), and combined cataract–glaucoma surgeries.

We welcome studies that evaluate postoperative visual acuity, intraocular pressure control, complication profiles, long-term surgical success, functional vision, and patient-reported quality-of-life outcomes. Real-world data studies, clinical trials, cohort studies, surgical technique evaluations, and evidence-based reviews—those that provide practical insights for ophthalmologists and glaucoma specialists—are particularly encouraged.

The aim is to support clinicians in selecting, optimizing, and personalizing surgical approaches for diverse patient populations.

Dr. Gloria Roberti
Dr. Manuele Michelessi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glaucoma surgery
  • visual acuity
  • intraocular pressure
  • surgical outcomes
  • trabeculectomy
  • microinvasive glaucoma surgery
  • postoperative complications
  • functional vision

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

12 pages, 1532 KB  
Article
Clinical Characteristics and Treatment Outcomes of Pediatric Glaucoma: A Retrospective Cohort Study
by Nancy N. Hanna, Doris Canes Napoles, Aaron Flickinger, Carter L. Carlos, Richard W. Hertle and Xiaoming Gong
J. Clin. Med. 2026, 15(9), 3551; https://doi.org/10.3390/jcm15093551 - 6 May 2026
Viewed by 261
Abstract
Objectives: This study aimed to evaluate clinical characteristics and treatment outcomes in a cohort of pediatric patients with glaucoma over 10-year period at a tertiary referral center. Methods: Medical records of patients younger than 18 years diagnosed with glaucoma between 1 [...] Read more.
Objectives: This study aimed to evaluate clinical characteristics and treatment outcomes in a cohort of pediatric patients with glaucoma over 10-year period at a tertiary referral center. Methods: Medical records of patients younger than 18 years diagnosed with glaucoma between 1 January 2013 and 31 December 2023 were retrospectively reviewed. Diagnoses were classified according to the Childhood Glaucoma Research Network (CGRN). Demographic data, clinical characteristics and surgical outcomes were analyzed. Statistical analyses included Student’s t-test, one-way ANOVA, and corresponding non-parametric methods (α = 0.05). Results: A total of 105 patients (168 eyes) were included, with a mean age of 5.52 ± 5.61 years, and a mean duration of follow-up of 5.41 ± 3.37 years. Mean baseline intraocular pressure (IOP) was 24.41 ± 10.85 mmHg. Secondary glaucoma was the predominant category (69%), led by glaucoma following cataract surgery (26%). Bilateral disease occurred in 60% of cases, more frequently in secondary forms. Surgery was performed in 57.4% of glaucomatous eyes. All subtypes except glaucoma following cataract surgery (GFCS) achieved significant reductions in IOP from baseline (p < 0.01). Despite effective IOP control, final visual acuity remained limited in many patients, especially those with glaucoma associated with non-acquired ocular anomalies or following cataract surgery. Worse baseline vision and higher presenting IOP were associated with poorer final acuity. Conclusions: Secondary glaucoma, particularly GFCS, was the most common form of pediatric glaucoma in this cohort. Although IOP control was generally successful, visual outcomes frequently remained suboptimal, highlighting the importance of early detection, comprehensive management, and close long-term monitoring. Full article
(This article belongs to the Special Issue Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life)
►▼ Show Figures

Figure 1

13 pages, 2760 KB  
Article
Evaluation of Changes in Ocular Tissue Elasticity Before and After Trabeculectomy Using Shear Wave Elastography
by Çiğdem Deniz Genç, Emre Aydın, Şaban Kılıç and Enes Gürün
J. Clin. Med. 2026, 15(9), 3238; https://doi.org/10.3390/jcm15093238 - 24 Apr 2026
Viewed by 300
Abstract
Objective: This study aimed to compare time-dependent changes in visual acuity (VA), central corneal thickness (CCT), intraocular pressure (IOP), and the structure and elasticity of ocular tissues, as measured by shear wave elastography (SWE), in the preoperative, postoperative 1st week, and 1st month [...] Read more.
Objective: This study aimed to compare time-dependent changes in visual acuity (VA), central corneal thickness (CCT), intraocular pressure (IOP), and the structure and elasticity of ocular tissues, as measured by shear wave elastography (SWE), in the preoperative, postoperative 1st week, and 1st month periods. Methods: This prospective observational study with repeated measurements included 22 individuals aged 44–86 years who underwent trabeculectomy for medically resistant glaucoma. VA, CCT, and IOP were measured preoperatively and at 1 week and 1 month postoperatively for the study. The elastic properties of ocular tissues were evaluated using the SWE method by obtaining quantitative measurements of lens SWE (LSWE), vitreous SWE (VSWE), optic nerve head SWE (OSWE), and retrobulbar fat SWE (RSWE). The changes in the obtained structural and elasticity parameters were compared preoperatively, 1 week postoperatively, and 1 month postoperatively. Results: When anterior segment parameters were evaluated in individuals who underwent trabeculectomy, there were significant differences in VA (p = 0.001, ƞp2 = 0.401), CCT (p = 0.001, ƞp2 = 0.806), and IOP (p = 0.001, ƞp2 = 0.853) values (p < 0.05). There was no statistically significant difference between preoperative and postoperative measurements at 1 week and 1 month for the elasticity parameters of LSWE, VSWE, OSWE, and RSWE (p > 0.05). Conclusions: This study suggests that the biomechanical adaptation of ocular tissues may be incomplete in the early postoperative period. Non-invasive methods such as SWE can be considered a potential tool for postoperative follow-up and predicting surgical success. Full article
(This article belongs to the Special Issue Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life)
►▼ Show Figures

Figure 1

11 pages, 220 KB  
Article
Comparison of Surgically Induced Astigmatism Between Baerveldt Glaucoma Implant Surgery and Trabeculectomy: A Retrospective Cohort Study
by Kengo Tanaka, Kentaro Iwasaki, Shogo Arimura, Marie Suzuki, Yoshihiro Takamura and Masaru Inatani
J. Clin. Med. 2026, 15(4), 1620; https://doi.org/10.3390/jcm15041620 - 20 Feb 2026
Viewed by 329
Abstract
Objectives: This study aimed to compare surgically induced corneal astigmatism (SIA) between Baerveldt glaucoma implant (BGI) surgery and trabeculectomy and to identify prognostic factors associated with SIA. Methods: This retrospective cohort study included 109 and 229 eyes that underwent BGI surgery [...] Read more.
Objectives: This study aimed to compare surgically induced corneal astigmatism (SIA) between Baerveldt glaucoma implant (BGI) surgery and trabeculectomy and to identify prognostic factors associated with SIA. Methods: This retrospective cohort study included 109 and 229 eyes that underwent BGI surgery and trabeculectomy, respectively, at Fukui University Hospital. Corneal astigmatism was assessed preoperatively, and at 6 months postoperatively, the mean SIA (M-SIA) and centroid SIA were calculated, and factors associated with M-SIA were determined. Results: BGI surgery was associated with greater SIA than trabeculectomy. Postoperative corneal astigmatism was −1.53 ± 1.01 D in the BGI group and −1.33 ± 0.92 D in the trabeculectomy group (p = 0.044). The M-SIA was significantly larger in the BGI group (1.41 ± 1.05 D vs. 0.94 ± 0.74 D, p < 0.01). Multivariate regression revealed that BGI surgery and lower preoperative corneal astigmatism were independently associated with greater M-SIA. Subgroup analysis revealed that older age and lower preoperative astigmatism were significant predictors of larger M-SIA in the BGI group, whereas only preoperative astigmatism was significant in the trabeculectomy group. Conclusions: BGI surgery was associated with greater and more variable SIA than trabeculectomy. Surgical type, baseline astigmatism, and age are important predictors of postoperative SIA. Full article
(This article belongs to the Special Issue Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life)
9 pages, 218 KB  
Article
Effect of Combined Cataract and Minimally Invasive Glaucoma Surgeries on Glaucoma-Specific Quality of Life
by Jonathan T. W. Au Eong, Jin Rong Low, Eva K. Fenwick, Hla M. Htoon, Shamira A. Perera, Tina T. Wong, Ecosse L. Lamoureux and Ryan E. K. Man
J. Clin. Med. 2026, 15(3), 1215; https://doi.org/10.3390/jcm15031215 - 4 Feb 2026
Viewed by 627
Abstract
Background: Minimally invasive glaucoma surgery, often performed with phacoemulsification (PHACO-MIGS), for the management of primary open angle glaucoma (POAG), has good clinical outcomes and safety profiles. However, few studies have comprehensively evaluated the impact of PHACO-MIGS on patients’ quality of life (QoL). [...] Read more.
Background: Minimally invasive glaucoma surgery, often performed with phacoemulsification (PHACO-MIGS), for the management of primary open angle glaucoma (POAG), has good clinical outcomes and safety profiles. However, few studies have comprehensively evaluated the impact of PHACO-MIGS on patients’ quality of life (QoL). We determined the post-operative effectiveness of PHACO-MIGS on glaucoma-specific QoL domains in mild–moderate POAG patients. Methods: In this prospective study, adults aged ≥ 21 years with mild–moderate POAG in one eye scheduled for PHACO-MIGS at the Singapore National Eye Centre were administered a digital patient-reported outcome measure (PROM) that utilizes computerized adaptive testing (CAT) to precisely estimate glaucoma-specific QoL across 12 different domains (GlauCATTM), pre-surgery and at 6 months post-surgery. The 12 domains included the following: Visual Symptoms (VSs), Ocular Comfort Symptoms (OSs), Emotional (EM), Activity Limitation (AL), Driving (DV), Lighting (LT), Mobility (MB), Treatment Convenience (TCV), Concerns (CNs), Social (SC), General Convenience (GCV), and Economic (EC). Clinical variables collected included intraocular pressure (IOP), better eye visual acuity (VA), visual field deficit (VFD) and number of glaucoma drops prescribed. Linear mixed models were utilized to determine the within-group changes in each domain, adjusted for relevant clinical, treatment and sociodemographic variables. Results: Of the 83 patients (mean age ± SD: 70.84 ± 6.70 years; 65.1% male; 90.4% Chinese), 61 (73.5%) underwent PHACO-MIGS with Hydrus® Microstent, and 22 (26.5%) with iStent® inject. Mean (SD) improvements in VA and IOP were observed post-surgery (0.11 [0.15] LogMAR units and 1.35 [4.20] mmHg, respectively), while VFD and the average number of anti-glaucoma medications prescribed decreased by 0.90 (2.97) dB and 1.30 (0.11) drops (all p < 0.05). Compared to pre-operative scores, four GlauCATTM domains [VSs (13.04%, p < 0.001; ES: 0.84), OSs (6.42%, p < 0.001; ES: 0.52), CNs (7.53%, p = 0.002; ES: 0.51), and GCV (6.34%, p = 0.004; ES: 0.45)] showed significant improvements post-surgery. The improvements across these four domains were driven primarily by a reduction in IOP and improvements in VA. Conclusions: Using a novel and AI-driven QoL PROM, we found significant post-operative improvements in Visual and Ocular Comfort Symptoms, Convenience, and Concerns in patients with POAG undergoing combined PHACO-MIGS, driven by improvements in IOP and VA post-surgery. Full article
(This article belongs to the Special Issue Clinical Outcomes of Glaucoma Surgery: Visual Acuity, Effectiveness and Quality of Life)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop