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Advances and Clinical Comparisons in Analgesia: Pharmacological, Non-Pharmacological, and Device-Based Approaches

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Anesthesiology".

Deadline for manuscript submissions: 20 November 2026 | Viewed by 1064

Special Issue Editors


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Guest Editor
Department of Anesthesiology and Pain Medicine, Chosun University Hospital, 365 Pilmun-daero, Dong-Gu, Gwangju 61453, Republic of Korea
Interests: acute pain management; chronic pain management; patient's safety; novel medicines and medical devices; clinical research
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Anaesthesiology and Pain Medicine, Ansan Hospital, Korea University, College of Medicine, Ansan 15355, Republic of Korea
Interests: organ transplantation; cardiopulmonary and anesthetic effects

Special Issue Information

Dear Colleagues,

Pain remains one of the most universal human experiences, and effective analgesia is essential across diverse clinical environments. These environments range from outpatient pain clinics managing acute and chronic pain to operating rooms where perioperative and anesthesia-related nociception must be carefully controlled. As clinical needs become increasingly complex, analgesic strategies now encompass pharmacological treatments, non-pharmaceutical modalities, and rapidly evolving device-based technologies.

This Special Issue, “Advances and Clinical Comparisons in Analgesia: Pharmacological, Non-Pharmacological, and Device-Based Approaches”, aims to explore and compare the effectiveness, safety, mechanisms, and clinical applicability of a wide range of analgesic interventions. Submissions are welcome from all stages of research, including preclinical studies, clinical translational research, and clinical investigations.

We encourage contributions addressing the following:

  • Acute and chronic pain management in pain clinics.
  • Perioperative pain control, including intubation response, induction pain, intraoperative nociception, and postoperative pain.
  • Comparative evaluations of pharmacological and non-pharmaceutical analgesia.
  • Device- and equipment-based approaches for pain control and monitoring (e.g., nociception monitoring systems, neuromodulation devices, nerve stimulators, and wearable sensors).
  • Multimodal analgesia and opioid-sparing strategies.
  • Regional anesthesia and nerve block techniques.
  • Advanced drug delivery systems and novel analgesic mechanisms.
  • Technology-driven and emerging approaches such as
    • AI-assisted pain assessment.
    • Virtual reality analgesia.
    • Digital therapeutics.
    • Wearable monitoring platforms.

This Special Issue aims to provide clinicians and researchers with a comprehensive, evidence-based understanding of current and emerging analgesic strategies, promoting improved pain management across both clinic- and operating room-based settings. Reviews and articles are welcome.

Best regards,

Prof. Dr. Sang Hun Kim
Dr. Yoon Ji Choi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • acute pain
  • chronic pain
  • postoperative pain
  • non-pharmaceutical
  • pharmaceutical
  • analgesia
  • clinical

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Published Papers (1 paper)

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20 pages, 1196 KB  
Systematic Review
Erector Spinae Plane Block Versus Thoracic Paravertebral Block for Postoperative Analgesia in Thoracic Surgery: A Systematic Review and Meta-Analysis of Randomized and Observational Studies
by Yoon Ji Choi, Hyun Kang and Sang Hun Kim
J. Clin. Med. 2026, 15(4), 1370; https://doi.org/10.3390/jcm15041370 - 9 Feb 2026
Viewed by 457
Abstract
Background/Objectives: Both erector spinae plane block (ESPB) and thoracic paravertebral block (TPVB) are widely used for thoracic surgery analgesia, but comparative evidence remains inconsistent. This meta-analysis compared their analgesic efficacy and safety with time-stratified analyses and trial sequential analysis (TSA). Methods: We searched [...] Read more.
Background/Objectives: Both erector spinae plane block (ESPB) and thoracic paravertebral block (TPVB) are widely used for thoracic surgery analgesia, but comparative evidence remains inconsistent. This meta-analysis compared their analgesic efficacy and safety with time-stratified analyses and trial sequential analysis (TSA). Methods: We searched MEDLINE, Embase, Web of Science, and CENTRAL (inception to January 2026) for randomized controlled trials (RCTs) and observational studies comparing ESPB with TPVB in adults undergoing thoracic surgery. Primary outcomes were pain scores at rest and during coughing at 0–6 h, 24 h, and 48 h postoperatively. Secondary outcomes included opioid consumption and adverse events. Random-effects meta-analyses were performed. Evidence certainty was assessed using GRADE. Results: Twenty-five studies (22 RCTs, 3 observational studies; 1847 patients) were included. TPVB provided superior early analgesia (0–6 h) at rest (SMD 0.25, 95% CI 0.03–0.47) and during coughing (SMD 0.28, 95% CI 0.02–0.54); TSA confirmed firm evidence for early pain at rest. Pain scores at 24 h and 48 h were comparable between techniques. TPVB reduced 24 h opioid consumption (SMD 0.42, 95% CI 0.11–0.73), but evidence certainty was low due to heterogeneity and insufficient information size by TSA. No differences were observed in postoperative nausea and vomiting or hypotension. Conclusions: ESPB and TPVB provide comparable analgesia beyond the early postoperative period. TPVB demonstrates superior early analgesia (0–6 h) with firm evidence, but opioid-sparing effects remain uncertain. Both techniques are safe. ESPB represents a practical alternative to TPVB, particularly where technical simplicity is prioritized. Full article
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