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Novel Insights into Antiplatelet Therapy in Cardiovascular Disease

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: closed (25 April 2025) | Viewed by 304

Special Issue Editor


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Guest Editor
Division of Cardiology, Department of Internal Medicine, Eunpyeong St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea
Interests: chronic total occlusion; percutaneous coronary intervention; coronary artery disease; drug-eluting stent; left coronary artery

Special Issue Information

Dear Colleagues,

Cardiovascular disease management has evolved significantly with advancements in antiplatelet therapy. This Special Issue delves into cutting-edge insights across several key areas of antiplatelet treatment in cardiovascular disease. It explores various modification strategies, such as de-escalation and escalation, with or without specific guidances, and the integration of novel oral anticoagulants with antiplatelet agents in coronary artery disease. Additionally, it includes rapidly evolving antiplatelet therapy strategies for structural heart disease interventions, such as transcatheter aortic valve replacement. Personalized antiplatelet therapy, which tailors treatment to individual patient needs and risk profiles, is also a critical focus. Research on diagnostic tools and strategies to support personalized approaches is particularly encouraged. Contributions to this Special Issue aim to provide comprehensive updates and discussions on optimizing therapeutic strategies, in managing various risk populations, thereby improving overall clinical outcomes.

Dr. Osung Kwon
Guest Editor

Manuscript Submission Information

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Keywords

  • antiplatelet therapy
  • cardiovascular disease
  • platelet aggregation
  • thrombosis prevention
  • platelet function
  • anticoagulation
  • personalized medicine

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Published Papers (1 paper)

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Review

22 pages, 1348 KiB  
Review
Bleeding Complications of Anticoagulation Therapy Used in the Treatment of Acute Coronary Syndromes—Review of the Literature
by Michał Kosowski, Maciej Kocjan, Michalina Mazurkiewicz, Marta Gamrot-Wrzoł, Sabina Ryl, Krzysztof Nowakowski, Jakub Kawecki, Tomasz Kukulski, Damian Kawecki and Beata Morawiec-Migas
J. Clin. Med. 2025, 14(10), 3391; https://doi.org/10.3390/jcm14103391 - 13 May 2025
Viewed by 48
Abstract
Bleeding complications are a significant concern in the management of acute coronary syndromes (ACS). The evidence from clinical trials demonstrates the need for balancing efficacy in reducing ischemic events with safety concerns, as bleeding events adversely affect prognosis and mortality. Pharmacological agents like [...] Read more.
Bleeding complications are a significant concern in the management of acute coronary syndromes (ACS). The evidence from clinical trials demonstrates the need for balancing efficacy in reducing ischemic events with safety concerns, as bleeding events adversely affect prognosis and mortality. Pharmacological agents like aspirin, P2Y12 inhibitors (e.g., prasugrel, ticagrelor), glycoprotein IIb/IIIa inhibitors, and heparins are fundamental to ACS treatment but carry varying bleeding risks depending on individual patient profile. Recent advancements in risk stratification tools have enabled tailored approaches to dual antiplatelet therapy (DAPT), optimizing its duration based on bleeding and thrombotic risks. Further Emerging therapies, including shortened DAPT protocols and P2Y12 inhibitor monotherapy, have shown promise in minimizing bleeding while maintaining clinical efficacy. The findings underscore the importance of personalized antithrombotic regimens in ACS management, emphasizing precise risk assessment to enhance outcomes and mitigate adverse events. This review examines the mechanisms, risk factors, and strategies to mitigate bleeding associated with anticoagulant and antiplatelet therapies in ACS. Full article
(This article belongs to the Special Issue Novel Insights into Antiplatelet Therapy in Cardiovascular Disease)
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