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Advances in Surgeries for Treating Common Skin Cancers
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Advances in Surgeries for Treating Common Skin Cancers

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 4966

Special Issue Editor

Dr. Monika Slowinska

E-Mail Website
Guest Editor
Dermatologic Department, Military Institute of Medicine–National Research Institute, Central Clinical Hospital Ministry of Defense, Warsaw, Poland
Interests: melanoma; non-melanoma skin cancer; dermoscopy; reflectance confocal microscopy; immunotherapy; targeted therapies; dermatologic adverse events of oncological treatment; ablative treatments
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past few decades, there has been a large increase in the incidence of melanoma and non-melanoma skin cancers (NMSCs). Although great therapeutic progress has been made in the treatment of locally advanced and metastatic cases, mainly thanks to immunotherapy and targeted therapy, patients with a large number of skin cancers within the face and scalp, skin mets, or genetic syndromes remain a huge challenge. Neoadjuvant treatment significantly changed patient outcomes as it has the potential to downstage unresectable disease and allow for curativeintent operative resection. However, the precise preoperative diagnostics and mapping of negative margins remains challenging in lentigo maligna /lentigo maligna melanoma lesions. Reflectance confocal microscopy and Mohs microsurgery have been used as supports, although are still not widely available. The use of electrochemo-therapy and ablative treatments are alternatives for multiple NMSCs and melanoma skin metastases. New methods and techniques for reconstructive surgery of the resultant defects, supported by tissue engineering and 3D modeling, are becoming more available and continue to evolve. This Special Issue aims to present not only current achievements in the field of skin cancer surgery, but also in an interdisciplinary context along with changing therapeutic strategies.

Dr. Monika Slowinska
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • melanoma
  • non-melanoma skin cancers
  • surgery
  • reconstruction
  • mohs microsurgery
  • ablative treatments
  • tissue engineering
  • pre-operative diagnostics

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Published Papers (3 papers)

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Research

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28 pages, 2520 KiB  
Article
Minimally Invasive Plasma Device Management of Multiple Benign Skin Cancers Associated with Rare Genodermatoses—Case Series and Review of the Therapeutic Methods
by Anna Płatkowska, Monika Słowińska, Joanna Zalewska, Zbigniew Swacha, Anna Szumera-Ciećkiewicz, Michał Wągrodzki, Janusz Patera, Katarzyna Łapieńska-Rey, Małgorzata Lorent, Iwona Ługowska, Piotr Rutkowski and Witold Owczarek
J. Clin. Med. 2024, 13(15), 4377; https://doi.org/10.3390/jcm13154377 - 26 Jul 2024
Cited by 1 | Viewed by 1994
Abstract
Background: Non-melanocytic benign skin tumours encompass a diverse group of lesions, classified based on their cellular origin, such as epidermal, vascular, fibrous, neural, muscle, and adnexal tumours. Though they often reveal solitary lesions, multiple skin tumours focus on genodermatoses. Each syndrome exhibits [...] Read more.
Background: Non-melanocytic benign skin tumours encompass a diverse group of lesions, classified based on their cellular origin, such as epidermal, vascular, fibrous, neural, muscle, and adnexal tumours. Though they often reveal solitary lesions, multiple skin tumours focus on genodermatoses. Each syndrome exhibits distinct clinical characteristics and potential complications, including cutaneous and extra-cutaneous malignancies, some of which are potentially life-threatening. Diagnosing genetic syndromes is complex and requires numerous histopathological and immunohistochemistry tests due to similarities between the adnexal tumours and basal cell carcinoma upon pathology. Methods: To illustrate the clinical practice, we conducted a retrospective case study that included eleven patients with genodermatoses referred to a tertiary dermatology clinic from September 2018 to April 2024. We have also conducted a research study on available treatment modalities in this setting. Results: Five patients with excellent aesthetic results were treated using a recently approved FDA plasma device. After searching SCOPUS and PubMed database records, we assessed 96 original articles to present current knowledge regarding the dermato-surgical approach. Conclusions: Multiple skin tumours, especially on the face, may significantly affect patients’ quality of life and have psychological consequences. An appropriate treatment selection tailored to the patient’s needs should be provided. There is no standardised treatment for multiple benign tumours in genodermatoses, and selected methods with varying efficacy are employed. We presented the utility of a new plasma device in these settings. Full article
(This article belongs to the Special Issue Advances in Surgeries for Treating Common Skin Cancers)
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12 pages, 1917 KiB  
Article
The Long-Term Results of Electrochemotherapy in the Treatment of Patients with Locoregionally Advanced, Unresectable Melanoma
by Marcin Zdzienicki, Marcin Ziętek, Maria Krotewicz, Agnieszka Ewert-Krzemieniewska and Piotr Rutkowski
J. Clin. Med. 2024, 13(13), 3705; https://doi.org/10.3390/jcm13133705 - 25 Jun 2024
Cited by 1 | Viewed by 1693
Abstract
Background/Objectives: Despite observing progress in recent years in the treatment of patients with advanced melanoma, the optimal management of locoregional recurrence has not been determined. Various methods are used to treat this group of patients. One of these methods is electrochemotherapy. The [...] Read more.
Background/Objectives: Despite observing progress in recent years in the treatment of patients with advanced melanoma, the optimal management of locoregional recurrence has not been determined. Various methods are used to treat this group of patients. One of these methods is electrochemotherapy. The present study presents the distant results in treating patients with the locoregional recurrence of melanoma, using the technique of electrochemotherapy. Methods: This study includes a retrospective analysis of 88 patients’ data with locoregional melanoma recurrence, treated with electrochemotherapy (ECT) between 2010 and 2023, in two reference centers. Results: Approximately 80% of patients responded to the ECT treatment, achieving partial or complete remission. In a multivariate analysis, statistically significant longer overall survival was found in the group of patients who achieved complete remission after ECT and were treated with immunotherapy. Discussion: The results may suggest the existence of synergy between ECT and immunotherapy. However, confirmation of this fact requires further prospective studies that will also establish the role of ECT in the combination treatment of patients with locoregional recurrence of melanoma. Full article
(This article belongs to the Special Issue Advances in Surgeries for Treating Common Skin Cancers)
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Review

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14 pages, 1822 KiB  
Review
Surgical Textbook Outcomes in the Era of Neoadjuvant Systemic Treatment for Skin Cancers
by Piotr Jan Błoński, Piotr Rutkowski, Krzysztof Ostaszewski, Maria Krotewicz and Anna M. Czarnecka
J. Clin. Med. 2024, 13(22), 6922; https://doi.org/10.3390/jcm13226922 - 17 Nov 2024
Viewed by 830
Abstract
Recent years have brought new, highly effective systemic treatments to clinical practice, which can be used to treat patients with locally advanced or metastatic skin cancers. Using these regimens in neoadjuvant strategy influences surgical treatment by facilitating surgical resection, avoiding extensive resections with [...] Read more.
Recent years have brought new, highly effective systemic treatments to clinical practice, which can be used to treat patients with locally advanced or metastatic skin cancers. Using these regimens in neoadjuvant strategy influences surgical treatment by facilitating surgical resection, avoiding extensive resections with complex reconstructions and even omitting surgery in some cases. Integrating systemic therapy with surgery is ongoing and requires novel quality measures of surgical treatment to capture the clinical benefits of multidisciplinary strategies better. The Textbook Outcome (TO) is a novel measure of surgical quality, which captures the short-term outcomes of surgery and reflects long-term survival. Textbook Outcomes match a particular type of surgery, are intuitive to interpret, and may be widely applied in surgical oncology and general surgery. Therefore, this review aims to describe recent findings on neoadjuvant skin cancer treatment and their implications for surgical proceedings in the context of Textbook Outcomes. Full article
(This article belongs to the Special Issue Advances in Surgeries for Treating Common Skin Cancers)
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