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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 20 May 2026 | Viewed by 3050

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Special Issue Editors

Dr. Stuti Misra

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Guest Editor

Associate Professor, Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Interests: corneal innervation; ocular surface disease; ocular imaging; dry eye disease; in vivo confocal microscopy of cornea; female hormones and the ocular surface
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Dr. Sònia Travé-Huarte

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Guest Editor Assistant

Optometry and Vision Sciences Research Group, Aston University, Birmingham B4 7ET, UK
Interests: dry eye disease; anterior ocular surface disease; meibomian gland dysfunction; corneal pain; tear film

Special Issue Information

Dear Colleagues,

We invite eye care clinicians, scientists, and researchers to submit their latest works for publication in our upcoming issue on the Diagnosis and Treatment of Ocular Surface Diseases. Advances in imaging, inflammatory markers, artificial intelligence, and personalised medicine are transforming the landscape of ocular surface disease care, offering new avenues for early detection and targeted therapies.

We welcome original research, clinical studies, systematic reviews, and randomised controlled trials that explore innovative diagnostic tools, novel treatment strategies, and the underlying pathophysiology of these conditions. Submissions covering emerging therapeutic agents, surgical interventions, and multidisciplinary approaches to care are especially encouraged.

Join us in advancing the understanding and management of ocular surface diseases to improve patient outcomes worldwide. Submit your manuscript today and contribute to the ongoing evolution of this critical field.

Dr. Stuti Misra
Guest Editor

Dr. Sònia Travé-Huarte
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

dry eye disease
ocular surface
anterior segment imaging
biomarkers
artificial intelligence
diagnostic tools
novel therapeutic agents
anterior eye care

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Published Papers (3 papers)

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Research

13 pages, 705 KB

Open AccessArticle

Validation and Comparative Analysis of a Contemporary Non-Contact Corneal Aesthesiometer

by Ally L. Xue, Alexis Ceecee Britten-Jones, Dian Zhuang, Catherine J. Jennings, Alex Muntz, Stuti L. Misra, Laura E. Downie and Jennifer P. Craig

J. Clin. Med. 2026, 15(8), 3145; https://doi.org/10.3390/jcm15083145 - 20 Apr 2026

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Abstract

Background: Corneal sensitivity is a key indicator of ocular surface health. This prospective, cross-sectional study evaluated agreement between corneal sensitivity thresholds obtained from equivalent stimulus settings on a contemporary, enhanced dual-temperature non-contact corneal aesthesiometer (NCCA) and a previously validated (standard) device. Methods: Central corneal sensitivity thresholds were measured in the right eyes of healthy participants using both devices. Participants with previous ocular surgery, laser treatment, trauma, contact lens wear, diabetes, or peripheral neuropathy were excluded. Sensitivity thresholds were determined using a forced-response, double-staircase protocol. Inter-device agreement was assessed using Bland–Altman analysis, and consistency was assessed using intraclass correlation coefficients. Results: Median corneal sensitivity thresholds in 51 healthy participants (32 female, 19 male; mean age: 33 ± 14 years) did not differ between enhanced (0.23 [0.18 to 0.38]) and standard (0.25 [0.15 to 0.35]) NCCA instruments (p = 0.73). Bland–Altman analysis demonstrated moderate inter-device agreement, with a mean difference of −0.01 mbar (95% limits of agreement: −0.41 to 0.39 mbar). Linear regression analysis identified greater measurement discrepancies at higher thresholds (p < 0.05), indicating greater variability in individuals with reduced corneal sensitivity. Conclusions: The enhanced NCCA yields reliable corneal sensitivity measures for a room-temperature stimulus and acceptable agreement with the existing (standard) model. Full article

(This article belongs to the Special Issue Diagnosis and Treatment of Ocular Surface Diseases)

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16 pages, 819 KB

Open AccessArticle

Exploring Evidence-Based Approaches to Ocular Allergy Among Australian Health Practitioners

by Ereeny Mikhail, Mohammadreza Mohebbi, Serap Azizoglu, Khyber Alam, Cenk Suphioglu and Moneisha Gokhale

J. Clin. Med. 2026, 15(1), 15; https://doi.org/10.3390/jcm15010015 - 19 Dec 2025

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Abstract

Background/Objectives: Ocular Allergy (OA) has profound effects on the quality of life (QoL) and ocular health of affected individuals. This study aimed to survey health practitioners in Australia on their knowledge and practices regarding currently available evidence-based diagnostic, treatment, and collaborative care approaches to OA. Methods: The Survey on Ocular Allergy for Health Practitioners (SOAHP), a validated tool, was distributed to various health practitioners across Australia in 2022. The survey data were analysed using descriptive statistics, Fisher’s exact test, and non-parametric tests. Results: A total of 155 participants completed the survey including Allergists/Immunologists (n = 6), General Practitioners (GPs) (n = 29), Ophthalmologists (n = 11), Optometrists (n = 66) and Pharmacists (n = 43). The survey revealed strengths and weakness in health practitioner approaches to OA. In terms of diagnosis, a significant 83.2% of participants were aware that itchy eyes are the hallmark symptom of OA; however, only 67.7% were aware that histamine is what causes the itching. Further to this, 57.4% of participants did not ask about QoL in clinical practice. In terms of management, only 30.3% were aware that some topical allergy eye drops act on eosinophils, and 74.9% were aware of the indications of mast cell stabiliser use. Finally, in terms of collaborative care, 68.4% did not believe there was a clear collaborative care model in Australia. Conclusions: This study revealed patterns in health practitioner approaches to OA. As expected, Ophthalmologists and Optometrists exhibited higher awareness and implementation of evidence-based approaches, compared to GPs and Pharmacists. However, these distinct patterns are likely influenced by differences in training and clinical responsibilities. Nonetheless, all practitioner groups showed gaps in knowledge and evidence-based practices surrounding OA. Thus, educational initiatives are required to ensure best patient-centered care is achieved, with reduced burden on the healthcare system. Full article

(This article belongs to the Special Issue Diagnosis and Treatment of Ocular Surface Diseases)

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12 pages, 1819 KB

Open AccessArticle

Preoperative Risk Factors for Dry Eye Symptoms After Cataract Surgery: Femtosecond Laser-Assisted Cataract Surgery (FLACS) Versus Standard Cataract Surgery (SCS)

by Elvia Mastrogiuseppe, Luca Lucchino, Francesca Giovannetti, Mattia D’Andrea, Davide Mastromarino, Alice Bruscolini, Alessandro Lambiase and Marco Marenco

J. Clin. Med. 2025, 14(19), 7091; https://doi.org/10.3390/jcm14197091 - 8 Oct 2025

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Abstract

Background: Despite technological advancements in cataract surgery, including Femtosecond Laser-Assisted Cataract Surgery (FLACS), postoperative dry eye disease (DED) remains a challenge, impacting patients’ quality of life. Identifying preoperative predictors of ocular discomfort could improve patient management. Methods: This exploratory prospective study compared the onset of DED symptoms and ocular surface changes after FLACS and standard cataract surgery (SCS). Twenty eyes were evaluated preoperatively and postoperatively, using Ocular Surface Disease Index (OSDI), Non-Invasive Break-Up Time (NI-BUT), Schirmer I Test, and Oxford Score. One-week OSDI was analyzed as the dependent variable using multivariable quantile regression (τ = 0.5), with baseline parameters (OSDI, Oxford score, Schirmer test, NI-BUT), age, BCVA, surgical technique, and cumulative dissipated energy (CDE) as predictors. Results: FLACS was associated with a transient worsening of OSDI at one week, which resolved by three months, whereas SCS showed a milder but more gradual increase. In multivariable analysis, baseline OSDI (β = 0.61, p < 0.001) and Oxford score (β = 5.42, p = 0.045) were independent predictors, while surgical technique and perioperative parameters were not significant. In a reduced model, both predictors confirmed their association. Subgroup analyses showed baseline OSDI as predictive only in FLACS. Conclusions: Preoperative ocular surface status emerges as the main determinant of early postoperative DED symptoms. Routine assessment of OSDI and Oxford scores may help identify at-risk patients and guide preventive strategies. Full article

(This article belongs to the Special Issue Diagnosis and Treatment of Ocular Surface Diseases)

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