Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
New Insights into Antimicrobial Stewardship
share announcement

New Insights into Antimicrobial Stewardship

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Infectious Diseases".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 2511

Special Issue Editor

Dr. Marco Bongiovanni

E-Mail
Guest Editor
Department of Infectious Diseases, Ente Ospedaliero Cantonale (EOC), Lugano, Switzerland
Interests: antimicrobial stewardship; HIV infection; COVID-19 infection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the role of antimicrobial stewardship programmes (ASPs) has become crucial for the optimal management of antibiotic infections, both in hospital and outpatient contexts. As a consequence, most hospitals have implemented dedicated ASPs.

The aim of this Special Issue is to propose and discuss new insights on this topic. Special considerations will be reserved concerning new approaches for measuring the efficacy of ASPs in different clinical settings and for different infections. The different ranges of antimicrobial resistances and antibiotic empiric treatments will be taken into consideration and compared to identify the possible common solutions to optimize antimicrobial treatments. Furthermore, new horizons for ASPs will be investigated, as outpatient parenteral antimicrobial therapy, antibiotic allergies, or therapeutic drug monitoring.

Dr. Marco Bongiovanni
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial stewardship
  • antibiotics
  • scores for AMS
  • antibiotic resistance
  • antibiotic infections

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

11 pages, 1645 KiB  
Article
Evaluation of Pharmacy Intern Interventions on Antimicrobial Use in University-Affiliated Hospitals: A Retrospective Analysis
by Tahani M. Almeleebia, Khalid M. Orayj, Wael A. Alghamdi, Mona A. Almanasef, Omar Hany and Ahmed R. N. Ibrahim
J. Clin. Med. 2024, 13(17), 5060; https://doi.org/10.3390/jcm13175060 - 26 Aug 2024
Viewed by 707
Abstract
Background: Appropriate use of antimicrobials is essential to enhance therapeutic safety and efficacy. Clinical pharmacists play a crucial role in optimizing antimicrobial use; however, the contribution of pharmacy interns in antimicrobial use has not been studied. The objective of this study was [...] Read more.
Background: Appropriate use of antimicrobials is essential to enhance therapeutic safety and efficacy. Clinical pharmacists play a crucial role in optimizing antimicrobial use; however, the contribution of pharmacy interns in antimicrobial use has not been studied. The objective of this study was to ascertain the quantity and nature of interventions related to antimicrobials documented by pharmacy interns, along with the rates at which physicians accepted these interventions. Methods: From August 2017 to March 2022, this study retrospectively evaluated antimicrobial-related interventions recorded by pharmacy interns during their rotations at King Khalid University. The categories of interventions included medication selection, addition of antimicrobials, dose or frequency adjustments, medication discontinuation, de-escalation, therapeutic drug monitoring, and others. Statistical analysis was conducted to identify patterns and correlations. Results: This study evaluated 1295 antimicrobial-related interventions, with high physician acceptance rates of 91.6% and 4.0% accepted with modifications. The most frequent interventions were dose/frequency adjustments (36.3%) and medication discontinuation (23%). Vancomycin, colistin, and meropenem were the most frequently intervened antimicrobials. Documented clinical outcomes included enhancing treatment efficacy (37.3%), reducing treatment toxicity (26.81%), and avoiding unnecessary antimicrobial exposure (21.8%). Significant correlations were observed between hospital units and intervention types, indicating unit-specific intervention patterns. Conclusions: Theses findings highlight the vital role of pharmacy interns in optimizing antimicrobial therapy. Future research should focus on evaluating the long-term clinical and economic benefits of their involvement. Full article
(This article belongs to the Special Issue New Insights into Antimicrobial Stewardship)
►▼ Show Figures

Figure 1

13 pages, 2034 KiB  
Article
Patients’ Opinions on Antibiotics in the Treatment of Dental Infections: A Cross-Sectional Survey
by Laura Domínguez-Domínguez, Pablo Castelo Baz, Alberto Cabrera-Fernandez, Daniel Cabanillas-Balsera, Manuel Pabon-Carrasco, Juan Jose Segura-Egea and Jenifer Martin-Gonzalez
J. Clin. Med. 2024, 13(7), 2099; https://doi.org/10.3390/jcm13072099 - 3 Apr 2024
Viewed by 1139
Abstract
Background: The aim of this study was to evaluate patients’ knowledge and perceptions of the use of systemic antibiotics in the treatment of endodontic infections and to determine the possible contribution of patients to the development of bacterial resistance. Methods: A [...] Read more.
Background: The aim of this study was to evaluate patients’ knowledge and perceptions of the use of systemic antibiotics in the treatment of endodontic infections and to determine the possible contribution of patients to the development of bacterial resistance. Methods: A total of 550 patients were asked to respond to a survey on the perception of systemic antibiotic use in the treatment of endodontic infections and antibiotic resistance during January 2022 and March 2023. A bivariate and multivariate analysis was performed to determine possible correlates in the population regarding antibiotic use in the endodontic world. Results: A total of 514 patients were included in the study, 65.9% of whom were women. While 34.6% of the population studied thought that it was always necessary to take antibiotics prior to endodontics, 49.4% considered that they were necessary after endodontics, regardless of the clinical symptoms. The prevalence of self-medication was 17.3%, and women self-medicate more than men, with significant differences (p < 0.05), although they have a greater knowledge of antibiotic resistance than men (p < 0.05). Forty-four percent of the population expected to take antibiotics when faced with dental pain, mainly women (p < 0.05). Conclusions: The general population is contributing to the serious problem of bacterial resistance. It is necessary to promote educational strategies focused on the correct use of antibiotics in the community. The worst results were found mainly in the population with a low level of education. The level of education was the variable that most influenced the knowledge and attitudes of the population, followed by the sex of the participants. Full article
(This article belongs to the Special Issue New Insights into Antimicrobial Stewardship)
►▼ Show Figures

Figure 1

Review

Jump to: Research

13 pages, 832 KiB  
Review
Breaking the Dogma of Intravenous Treatment for Infective Endocarditis: A Systematic Review and Meta-Analysis
by Beatrice Barda, Christian Schindler, Enos Bernasconi and Marco Bongiovanni
J. Clin. Med. 2024, 13(24), 7518; https://doi.org/10.3390/jcm13247518 - 10 Dec 2024
Viewed by 292
Abstract
Introduction: The treatment of infective endocarditis (IE) is based on long intravenous administration of antibiotics. This is still a hard-to-die dogma. Throughout the years, different researchers have attempted to demonstrate the safety and efficacy of an oral switch of the antibiotic regimen, with [...] Read more.
Introduction: The treatment of infective endocarditis (IE) is based on long intravenous administration of antibiotics. This is still a hard-to-die dogma. Throughout the years, different researchers have attempted to demonstrate the safety and efficacy of an oral switch of the antibiotic regimen, with only scarce success. Nevertheless, in recent years, different reports have evaluated the efficacy of oral switch therapy in selected patients. Due to the lack of large trials, a meta-analysis could be useful to evaluate the potential benefits of early oral switch therapy not only in terms of microbiological cure but also in terms of relapse, mortality, and length of hospital stay (LOS). Methods: We conducted a Medline search, from which we were able to extrapolate 29 papers on IE treatment; the inclusion criteria were met by six papers only. Three trials were not randomized studies; therefore, we conducted the analysis both including and excluding the mentioned papers. Results: Overall, we conducted our analysis on 840 patients who received intravenous treatment and 677 who received oral treatment. Our results confirmed that oral switch therapy represents an option in selected patients, with a reduction in the relapse rate (OR: 0.54, 95% CI: 0.31–0.92). No statistically significant differences were observed for treatment failure (OR: 0.74, 95% CI: 0.48–1.14), length of hospitalization (OR: −0.42, 95% CI: −1.55–0.71), complication rate (OR: 0.38, 95% CI: 0.1–1.54), and mortality (OR: 0.52, 95% CI: 0.22–1.22). Discussion: Our results allow us to conclude that oral switch therapy is a feasible option in clinically stable patients with infective endocarditis. Moreover, oral switch therapy seems to perform significantly better than intravenous treatment in terms of relapse of infection. The data further support the implementation of oral switch therapy in infective endocarditis. Full article
(This article belongs to the Special Issue New Insights into Antimicrobial Stewardship)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-3
Back to TopTop