Special Issue "Metals in Neurodegenerative Diseases"
Deadline for manuscript submissions: 30 June 2019
Prof. Dr. Blaine Roberts
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
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Interests: metalloproteomics; mass spectrometry; Neurodegeneration; Alzheimer’s disease; amyotrophic lateral sclerosis; amyloid beta; biomarkers; native protein purification
The human brain is perhaps the most complex organ in existence. In addition to this, it has considerable and varied metabolic requirements that must be consistently maintained throughout the lifespan of an individual. This is underlined by the fact that it consumes approximately 25% of an individual’s daily energy resources, despite accounting for only 2% of total body weight. As a direct consequence of high nutrient input, the brain is rich in essential elements (particularly Fe, Cu, and Zn), with concentrations in some regions of the brain equalling or exceeding those found in the liver. Alarmingly, during neurodegeneration, the balance of essential trace elements and the metalloenzymes that use them is disrupted. Although the measurement of total essential element abundances is important, it only yields a fraction of the story. Currently, our understanding of the relationships between changes in trace elements and the function of their related metalloproteins is limited. In this Special Issue, we highlight the most current discoveries in this area: (1) The consequences of metal mis-incorporation and absence to proper protein structure and function, (2) The recent advances made in speciation techniques and their application to direct measurement of metalloenzymes, and (3) New therapeutic strategies aimed at targeting metal dyshomeostasis.
Prof. Dr. Blaine Roberts
Manuscript Submission Information
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- essential minerals
- trace elements
- metal protein attenuating compounds
- Alzheimer’s Disease
- Parkinson’s Disease
- amyotrophic lateral sclerosis
- Wilson’s disease
- Menkes disease