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Inorganics
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Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition
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Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1844

Special Issue Editors

Dr. Tamara Topala

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Guest Editor
Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: chemistry of transition metal complexes; nanoparticles as drug delivery systems; antitumor activity
Special Issues, Collections and Topics in MDPI journals
Dr. Andreea Elena Bodoki

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Guest Editor
Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: bioinorganic chemistry; nanotechnology; molecular imprinting
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Luminita Simona Oprean

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Guest Editor
Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: transition metal chemistry; biomolecules interactions; antitumor activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The exciting research fields of bioinorganic and inorganic medicinal chemistry are expanding, providing new perspectives regarding the interaction of inorganic compounds with biological matrixes and their potential as therapeutic and diagnosis agents. Metal complexes, especially those containing transition metal ions, are valuable platforms for drug design and have proven their biological properties many times over, with important progress in obtaining new compounds with antitumor, antibacterial, antiviral, and antifungal activity.

Given the success of the First Edition of this Special Issue, a second volume was launched, seeking to gather original research papers and comprehensive review articles focusing on bioactive compounds. Original research articles as well as reviews are welcome, intending to highlight recent advances concerning the following issues:

  • The role of metal ions in biological environments;
  • Synthesis, physicochemical characterization of metal complexes, and evaluation of their biological and therapeutic potential;
  • The interaction of coordination and organometallic compounds with biological macromolecules, such as nucleic acids and proteins;
  • Coordination compounds as metalloenzymes mimics;
  • Metallic and metal oxide nanoparticles as therapeutic and diagnosis agents.

Dr. Tamara Topala
Dr. Andreea Elena Bodoki
Prof. Dr. Luminita Simona Oprean
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transition metal complexes
  • biomolecules interactions
  • enzyme mimics
  • therapeutic platforms
  • diagnosis agents
  • biological activity

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Related Special Issue

Published Papers (3 papers)

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Research

22 pages, 4411 KiB  
Article
Synthesis, Structural Characterization, and In Silico Antiviral Prediction of Novel DyIII-, YIII-, and EuIII-Pyridoxal Helicates
by Francisco Mainardi Martins, Yuri Clemente Andrade Sokolovicz, Morgana Maciél Oliveira, Carlos Serpa, Otávio Augusto Chaves and Davi Fernando Back
Inorganics 2025, 13(8), 252; https://doi.org/10.3390/inorganics13080252 - 23 Jul 2025
Viewed by 404
Abstract
The synthesis and structural characterization of three new triple-stranded helical complexes ([Dy2(L2)3]2Cl∙15H2O (C1), [Y2(L2)3]3(NO3)Cl∙14H2O∙DMSO (C2), and [Eu2(L4) [...] Read more.
The synthesis and structural characterization of three new triple-stranded helical complexes ([Dy2(L2)3]2Cl∙15H2O (C1), [Y2(L2)3]3(NO3)Cl∙14H2O∙DMSO (C2), and [Eu2(L4)3]∙12H2O (C3), where L2 and L4 are ligands derived from pyridoxal hydrochloride and succinic or adipic acid dihydrazides, respectively, were described. The X-ray data, combined with spectroscopic measurements, indicated that L2 and L4 act as bis-tridentate ligands, presenting two tridentate chelating cavities O,N,O to obtain the dinuclear complexes C1–C3. Their antiviral profile was predicted via in silico calculations in terms of interaction with the structural severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein in the down- and up-states and complexed with the cellular receptor angiotensin-converting enzyme 2 (ACE2). The best affinity energy values (−9.506, −9.348, and −9.170 kJ/mol for C1, C2, and C3, respectively) were obtained for the inorganic complexes docked in the model spike-ACE2, with C1 being suggested as the most promising candidate for a future in vitro validation. The obtained in silico antiviral trend was supported by the prediction of the electronic and physical–chemical properties of the inorganic complexes via the density functional theory (DFT) approach, representing an original and relevant contribution to the bioinorganic and medicinal chemistry fields. Full article
(This article belongs to the Special Issue Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition)
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19 pages, 4875 KiB  
Article
Synthesis, Characterization, and Biological Evaluation of Some 3d Metal Complexes with 2-Benzoylpyridine 4-Allylthiosemicarbazone
by Vasilii Graur, Ianina Graur, Pavlina Bourosh, Victor Kravtsov, Carolina Lozan-Tirsu, Greta Balan, Olga Garbuz, Victor Tsapkov and Aurelian Gulea
Inorganics 2025, 13(7), 249; https://doi.org/10.3390/inorganics13070249 - 21 Jul 2025
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Abstract
The eight new copper(II), nickel(II), zinc(II), and iron(III) coordination compounds [Cu(L)Cl]2 (1), [Cu(L)Br]2 (2), [Cu(L)(NO3)]2 (3), [Cu(phen)(L)]NO3 (4), [Ni(HL)2](NO3)2·H2O (5 [...] Read more.
The eight new copper(II), nickel(II), zinc(II), and iron(III) coordination compounds [Cu(L)Cl]2 (1), [Cu(L)Br]2 (2), [Cu(L)(NO3)]2 (3), [Cu(phen)(L)]NO3 (4), [Ni(HL)2](NO3)2·H2O (5), [Ni(HL)2]Cl2 (6), [Zn(L)2]·0.125H2O (7), and [Fe(L)2]Cl (8), where HL stands for 2-benzoylpyridine 4-allylthiosemicarbazone, were synthesized and characterized. 1H, 13C NMR, and FTIR spectroscopies were used for characterization of the HL thiosemicarbazone. The elemental analysis, the FTIR spectroscopy, and the study of molar electrical conductivity were used for characterization of the coordination compounds 1–8. Also, the crystal structures of HL, its salts ([H2L]Cl; [H2L]NO3), and complexes 1, 3, 5, 7, and 8 were determined using single-crystal X-ray diffraction analysis. Complexes 5, 7, 8 have mononuclear structures, while copper(II) complexes 1 and 3 have a dimeric structure with the sulfur atoms of the thiosemicarbazone ligand bridging two copper atoms together. Thiosemicarbazone HL and the complexes manifest antibacterial and antifungal activities. The studied substances are more active towards Gram-negative bacteria than towards Gram-positive bacteria and fungi. Complex 1 is the most active one towards Gram-positive bacteria and C. albicans, while the introduction of 1,10-phenanthroline into the inner sphere enhances the activity towards Gram-negative bacteria. Thiosemicarbazone and complexes 6 and 7 manifest antiradical activity that exceeds the activity of Trolox. HL and complex 1 manifest antiproliferative activity towards HL-60 cancer cells which exceeds the activity of their analogs with 2-formyl-/2-acetylpyridine 4-allylthiosemicarbazone. Full article
(This article belongs to the Special Issue Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition)
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20 pages, 9373 KiB  
Article
In Vitro Antibacterial Activities and Calf Thymus DNA–Bovine Serum Albumin Interactions of Tridentate NNO Hydrazone Schiff Base–Metal Complexes
by Maida Katherine Triviño-Rojas, Santiago José Jiménez-Lopez, Richard D’Vries, Alberto Aragón-Muriel and Dorian Polo-Cerón
Inorganics 2025, 13(7), 213; https://doi.org/10.3390/inorganics13070213 - 25 Jun 2025
Viewed by 889
Abstract
Their demonstrable bioactive characteristics, coupled with their wide structural diversity and coordination versatility, render Schiff bases and their coordination complexes biologically active compounds demonstrating outstanding properties. This research describes the synthesis and characterization of new Cu(II) and Ni(II) complexes with an NNO-donor hydrazone [...] Read more.
Their demonstrable bioactive characteristics, coupled with their wide structural diversity and coordination versatility, render Schiff bases and their coordination complexes biologically active compounds demonstrating outstanding properties. This research describes the synthesis and characterization of new Cu(II) and Ni(II) complexes with an NNO-donor hydrazone ligand (HL). The crystal structure of the HL ligand was determined through single-crystal X-ray diffraction studies. The in vitro antibacterial activities of the HL ligand and its metal(II) complexes against Gram-positive and Gram-negative bacteria demonstrated that the metal(II) complexes displayed greater antimicrobial activities compared to the free Schiff base ligand. Furthermore, the interaction of the ligand and the complexes with calf thymus DNA (CT-DNA) was explored through electronic absorption and viscosity measurements, suggesting intercalation as the most likely mode of binding. The compounds promoted oxidative DNA cleavage, as demonstrated by the strand breaks of the pmChery plasmid under oxidative stress conditions. Finally, fluorescence spectroscopy also revealed the strong binding affinity of these compounds for bovine serum albumin (BSA). Full article
(This article belongs to the Special Issue Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition)
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