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Inorganics
Special Issues
Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition
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Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Bioinorganic Chemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 903

Special Issue Editors

Dr. Tamara Topala

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Guest Editor
Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: chemistry of transition metal complexes; nanoparticles as drug delivery systems; antitumor activity
Special Issues, Collections and Topics in MDPI journals
Dr. Andreea Elena Bodoki

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Guest Editor
Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: bioinorganic chemistry; nanotechnology; molecular imprinting
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Luminita Simona Oprean

E-Mail Website
Guest Editor
Department of Inorganic Chemistry, Faculty of Pharmacy, “Iuliu-Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
Interests: transition metal chemistry; biomolecules interactions; antitumor activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The exciting research fields of bioinorganic and inorganic medicinal chemistry are expanding, providing new perspectives regarding the interaction of inorganic compounds with biological matrixes and their potential as therapeutic and diagnosis agents. Metal complexes, especially those containing transition metal ions, are valuable platforms for drug design and have proven their biological properties many times over, with important progress in obtaining new compounds with antitumor, antibacterial, antiviral, and antifungal activity.

Given the success of the First Edition of this Special Issue, a second volume was launched, seeking to gather original research papers and comprehensive review articles focusing on bioactive compounds. Original research articles as well as reviews are welcome, intending to highlight recent advances concerning the following issues:

  • The role of metal ions in biological environments;
  • Synthesis, physicochemical characterization of metal complexes, and evaluation of their biological and therapeutic potential;
  • The interaction of coordination and organometallic compounds with biological macromolecules, such as nucleic acids and proteins;
  • Coordination compounds as metalloenzymes mimics;
  • Metallic and metal oxide nanoparticles as therapeutic and diagnosis agents.

Dr. Tamara Topala
Dr. Andreea Elena Bodoki
Prof. Dr. Luminita Simona Oprean
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transition metal complexes
  • biomolecules interactions
  • enzyme mimics
  • therapeutic platforms
  • diagnosis agents
  • biological activity

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Published Papers (1 paper)

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Research

20 pages, 9373 KiB  
Article
In Vitro Antibacterial Activities and Calf Thymus DNA–Bovine Serum Albumin Interactions of Tridentate NNO Hydrazone Schiff Base–Metal Complexes
by Maida Katherine Triviño-Rojas, Santiago José Jiménez-Lopez, Richard D’Vries, Alberto Aragón-Muriel and Dorian Polo-Cerón
Inorganics 2025, 13(7), 213; https://doi.org/10.3390/inorganics13070213 - 25 Jun 2025
Viewed by 709
Abstract
Their demonstrable bioactive characteristics, coupled with their wide structural diversity and coordination versatility, render Schiff bases and their coordination complexes biologically active compounds demonstrating outstanding properties. This research describes the synthesis and characterization of new Cu(II) and Ni(II) complexes with an NNO-donor hydrazone [...] Read more.
Their demonstrable bioactive characteristics, coupled with their wide structural diversity and coordination versatility, render Schiff bases and their coordination complexes biologically active compounds demonstrating outstanding properties. This research describes the synthesis and characterization of new Cu(II) and Ni(II) complexes with an NNO-donor hydrazone ligand (HL). The crystal structure of the HL ligand was determined through single-crystal X-ray diffraction studies. The in vitro antibacterial activities of the HL ligand and its metal(II) complexes against Gram-positive and Gram-negative bacteria demonstrated that the metal(II) complexes displayed greater antimicrobial activities compared to the free Schiff base ligand. Furthermore, the interaction of the ligand and the complexes with calf thymus DNA (CT-DNA) was explored through electronic absorption and viscosity measurements, suggesting intercalation as the most likely mode of binding. The compounds promoted oxidative DNA cleavage, as demonstrated by the strand breaks of the pmChery plasmid under oxidative stress conditions. Finally, fluorescence spectroscopy also revealed the strong binding affinity of these compounds for bovine serum albumin (BSA). Full article
(This article belongs to the Special Issue Metal-Based Compounds: Relevance for the Biomedical Field, 2nd Edition)
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