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State-of-the-Art Molecular Endocrinology and Metabolism in Japan

A topical collection in International Journal of Molecular Sciences (ISSN 1422-0067). This collection belongs to the section "Molecular Endocrinology and Metabolism".

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Editor


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Collection Editor
1. Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine, Minami Kogushi 1-1-1, Ube Yamaguchi 755-8505, Japan
2. Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Interests: adenylate kinase; liver fibrosis; energy metabolism; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

Based on long-term traditions of fundamental science in Japan, this Topical Collection aims to provide an up-to-date and comprehensive overview on the state of the art of endocrinology and metabolism research nationwide.

All kinds of arcticles are welcome, including original investigations and reviews in the field. Topics of interest include, but are not limited to, the following:

  • Endocrine systems and endocrine-related diseases;
  • Molecular, cellular, genetic, epigenetic, developmental approaches, and animal models;
  • Novel insights into physiology, pathophysiology, and therapeutics;
  • Neuroendocrinology and neuroendocrine control of endocrine axes;
  • Classical glands (thyroid, adrenal, pituitary, parathyroid, testis, ovary, pituitary, etc.) and other endocrine systems, such as gut, bone, liver, etc.;
  • Lipids and bone metabolism;
  • Hormones, paracrine factors, receptors and binding components, nuclear receptors membrane receptors, signal transduction pathway;
  • Steroid biosynthetic enzymes, metabolism of hormones, neurotransmitters, etc.;
  • Cellular interactions and factors involved;
  • Energy expenditure;
  • Diabetes;
  • Infertility and reproductive diseases;
  • Obesity;
  • Osteoporosis;
  • Aging;
  • Endocrine-related tumor and cancer;
  • Endocrine disruption;
  • Cross-disciplinary and integrative studies;
  • Comparative aspects of endocrinology.

Dr. Koichi Fujisawa
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

2023

Jump to: 2022

16 pages, 767 KiB  
Review
Regulation of Adenine Nucleotide Metabolism by Adenylate Kinase Isozymes: Physiological Roles and Diseases
by Koichi Fujisawa
Int. J. Mol. Sci. 2023, 24(6), 5561; https://doi.org/10.3390/ijms24065561 - 14 Mar 2023
Cited by 6 | Viewed by 2208
Abstract
Adenylate kinase (AK) regulates adenine nucleotide metabolism and catalyzes the ATP + AMP ⇌ 2ADP reaction in a wide range of organisms and bacteria. AKs regulate adenine nucleotide ratios in different intracellular compartments and maintain the homeostasis of the intracellular nucleotide metabolism necessary [...] Read more.
Adenylate kinase (AK) regulates adenine nucleotide metabolism and catalyzes the ATP + AMP ⇌ 2ADP reaction in a wide range of organisms and bacteria. AKs regulate adenine nucleotide ratios in different intracellular compartments and maintain the homeostasis of the intracellular nucleotide metabolism necessary for growth, differentiation, and motility. To date, nine isozymes have been identified and their functions have been analyzed. Moreover, the dynamics of the intracellular energy metabolism, diseases caused by AK mutations, the relationship with carcinogenesis, and circadian rhythms have recently been reported. This article summarizes the current knowledge regarding the physiological roles of AK isozymes in different diseases. In particular, this review focused on the symptoms caused by mutated AK isozymes in humans and phenotypic changes arising from altered gene expression in animal models. The future analysis of intracellular, extracellular, and intercellular energy metabolism with a focus on AK will aid in a wide range of new therapeutic approaches for various diseases, including cancer, lifestyle-related diseases, and aging. Full article
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2022

Jump to: 2023

14 pages, 1353 KiB  
Article
Bile Acid–Drug Interaction via Organic Anion-Transporting Polypeptide 4C1 Is a Potential Mechanism of Altered Pharmacokinetics of Renally Excreted Drugs
by Minami Yamauchi, Toshihiro Sato, Ayana Otake, Masaki Kumondai, Yu Sato, Masafumi Kikuchi, Masamitsu Maekawa, Hiroaki Yamaguchi, Takaaki Abe and Nariyasu Mano
Int. J. Mol. Sci. 2022, 23(15), 8508; https://doi.org/10.3390/ijms23158508 - 31 Jul 2022
Cited by 2 | Viewed by 1931
Abstract
Patients with liver diseases not only experience the adverse effects of liver-metabolized drugs, but also the unexpected adverse effects of renally excreted drugs. Bile acids alter the expression of renal drug transporters, however, the direct effects of bile acids on drug transport remain [...] Read more.
Patients with liver diseases not only experience the adverse effects of liver-metabolized drugs, but also the unexpected adverse effects of renally excreted drugs. Bile acids alter the expression of renal drug transporters, however, the direct effects of bile acids on drug transport remain unknown. Renal drug transporter organic anion-transporting polypeptide 4C1 (OATP4C1) was reported to be inhibited by chenodeoxycholic acid. Therefore, we predicted that the inhibition of OATP4C1-mediated transport by bile acids might be a potential mechanism for the altered pharmacokinetics of renally excreted drugs. We screened 45 types of bile acids and calculated the IC50, Ki values, and bile acid–drug interaction (BDI) indices of bile acids whose inhibitory effect on OATP4C1 was >50%. From the screening results, lithocholic acid (LCA), glycine-conjugated lithocholic acid (GLCA), and taurine-conjugated lithocholic acid (TLCA) were newly identified as inhibitors of OATP4C1. Since the BDI index of LCA was 0.278, LCA is likely to inhibit OATP4C1-mediated transport in clinical settings. Our findings suggest that dose adjustment of renally excreted drugs may be required in patients with renal failure as well as in patients with hepatic failure. We believe that our findings provide essential information for drug development and safe drug treatment in clinics. Full article
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