Latest Review Papers in Biochemistry
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Editors
Prof. Dr. Cheng-Yang Huang
Prof. Dr. Cheng-Yang Huang
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Collection Editor
1. Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan
2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung City 402, Taiwan
Interests: plant extracts; natural products; enzyme inhibitors; molecular mechanisms
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Athanasios Salifoglou
Prof. Dr. Athanasios Salifoglou
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Website
Collection Editor
School of Chemical Engineering, Faculty of Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Interests: bioinorganic chemistry; molecular engineering; hybrid materials; metallodrugs; cell (patho)physiologies; neurodegeneration; neoplastic process
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
Dear Colleagues,
This Topical Collection aims to collect high-quality review papers across all fields of biochemistry. Biochemistry remains a cornerstone of the life sciences, bridging the fields of molecular biology, structural biology, enzymology, metabolism, and drug development. As experimental and computational technologies continue to advance rapidly, there is an increasing demand for timely and comprehensive review articles that synthesize recent discoveries and emerging concepts from diverse areas of biochemistry. We welcome review articles that summarize cutting-edge progress, explore unresolved questions, highlight new techniques or methodologies, and offer forward-looking perspectives in the field. Topics of interest of this Special Issue include but are not limited to the following: enzyme structure, function, and regulation; protein–protein and protein–ligand interactions; metabolic and signaling pathways; nucleic acid chemistry and RNA biology; biochemical mechanisms of disease; redox biology and oxidative stress; molecular docking and computational modeling; biochemical approaches in drug discovery; synthetic and systems biochemistry; emerging biotechnological applications of biochemistry. We also strongly encourage contributions reviewing the biological activities of bioactive constituents derived from plant extracts.
Prof. Dr. Cheng-Yang Huang
Prof. Dr. Athanasios Salifoglou
Collection Editors
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Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- enzyme function
- protein-ligand interaction
- structure
- mechanism
- biomolecule
- signaling pathway
- nucleic acid chemistry
- redox biology
- drug discovery
- natural product
Published Papers (2 papers)
Open AccessReview
Glial Cells as Key Mediators in the Pathophysiology of Neurodegenerative Diseases
by
Katarzyna Bogus, Nicoletta Marchesi, Lucrezia Irene Maria Campagnoli, Alessia Pascale and Artur Pałasz
Cited by 1 | Viewed by 1720
Abstract
Neurodegenerative disorders are characterized by progressive neuronal loss and dysfunction, yet increasing evidence indicates that glial cells are central mediators of both disease initiation and progression. Astrocytes, microglia, and oligodendrocyte lineage cells modulate neuronal survival by regulating neuroinflammation, metabolic support, synaptic maintenance, and
[...] Read more.
Neurodegenerative disorders are characterized by progressive neuronal loss and dysfunction, yet increasing evidence indicates that glial cells are central mediators of both disease initiation and progression. Astrocytes, microglia, and oligodendrocyte lineage cells modulate neuronal survival by regulating neuroinflammation, metabolic support, synaptic maintenance, and proteostasis. However, dysregulated glial responses, including chronic microglial activation, impaired phagocytosis, altered cytokine production, and mitochondrial dysfunction, contribute to persistent inflammation and structural degeneration observed across Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease and multiple sclerosis. Recent advances in single-cell and spatial omics have revealed extensive glial heterogeneity and dynamic shifts between neuroprotective and neurotoxic phenotypes, emphasizing the context-dependent nature of glial activity. This review summarizes current knowledge regarding the multifaceted involvement of glial cells in neurodegenerative disorders.
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Open AccessReview
The Involvement of Ceramide, Sphingosine-1-Phosphate and Ganglioside GM1 in Regulating Some Nervous System Functions
by
Paola Giussani, Laura Mauri and Sandro Sonnino
Cited by 3 | Viewed by 1752
Abstract
Sphingolipids are a large group of molecules, crucial components of all mammalian cells, that are particularly abundant in the central and peripheral nervous system and associated with important human brain functions. Sphingolipids are necessary for membrane organization and driving functions. Ceramide, sphingosine-1-phosphate and
[...] Read more.
Sphingolipids are a large group of molecules, crucial components of all mammalian cells, that are particularly abundant in the central and peripheral nervous system and associated with important human brain functions. Sphingolipids are necessary for membrane organization and driving functions. Ceramide, sphingosine-1-phosphate and GM1, show bioactive properties. Ceramide and sphingosine-1-phosphate play a crucial role in the regulation of physio-pathological conditions. Small changes in their levels, in the ratio sphingosine-1-phosphate/ceramide as well as in chain length profiles of sphingolipids contribute to alter signaling pathways in neurons and glia, contributing to various neurological disorders. GM1 is considered a neurotrophic and neuroprotective compound and seems to be necessary for the correct functioning of neuronal membrane receptors, suggesting that a reduction in its level in the brain can be involved in neurodegenerative diseases. In this review, we give an overview of sphingolipid metabolism, summarizing the role of ceramide, sphingosine-1-phosphate, and GM1 in maintaining human health.
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