International Journal of Molecular Sciences

International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Molecular Insights into Ischemia/Reperfusion: 3rd Edition

edited by

Moo-Ho Won

submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open

Keywords: vital organs; ischemic injury; cell and organ dysfunction; oxidative stress; inflammation; excitotoxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunobiology of Metabolic Regulation and Aging

edited by

Hiroshi Nishiura

and Masaki Ohmuraya

submission deadline 28 Feb 2027 | Viewed by 33 | Submission Open

Keywords: age-related diseases; aging vascular endothelial cells; healthy lifespan; organ-specific niche; senescence-associated (SA) immune cells; senescence-associated (SA) metabolism; super-aging society; tertiary lymphoid structures

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Advanced Targeted Intervention Strategies for Neurodegenerative Diseases

edited by

Ashu Johri

submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open

Keywords: Alzheimer's disease; Parkinson’s disease; mitochondria; therapeutics; autophagy; cell-death; nanomedicine; gene therapy; drug delivery

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research and Targeted Therapies of Cardiovascular Diseases

edited by Christos Kourek

submission deadline 28 Feb 2027 | Viewed by 32 | Submission Open

Keywords: cardiovascular diseases; molecular mechanisms; targeted therapy; endothelial progenitor cells; endothelial dysfunction; angiogenesis and vascular repair; cardiac regeneration; biomarkers; precision medicine; regenerative medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tumor Microenvironment and Precision Therapeutics: From Biological Insights to Clinical Applications in Solid and Hematological Malignancies

edited by

Matin Sheriff

and Eleni D. Kapsali

submission deadline 28 Feb 2027 | Viewed by 31 | Submission Open

Keywords: tumor microenvironment; precision oncology; precision therapeutics; solid tumors; hematological malignancies; tumor heterogeneity; immunotherapy; targeted therapy; cellular therapy; therapeutic resistance; biomarkers; molecular profiling; single-cell sequencing; stromal cells; cancer-associated fibroblasts; extracellular matrix; extracellular vesicles; liquid biopsy; translational oncology; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Immune Responses in Infectious Diseases: From Genes and Protein Interactions to Disease Outcomes

edited by

Jeane Eliete Laguila Visentainer

submission deadline 28 Feb 2027 | Viewed by 31 | Submission Open

Keywords: infectious diseases; immune response; molecular immunology; host–pathogen interactions; immune-related genes; protein–protein interactions; cytokines; biomarkers; molecular mechanisms; disease severity; mortality; genomics; transcriptomics; proteomics; bioinformatics; precision medicine

(This special issue belongs to the Section Molecular Immunology)

State-of-the-Art "Molecular Oncology" in Spain

edited by

Isidro Machado

submission deadline 28 Feb 2027 | Viewed by 27 | Submission Open

Keywords: molecular oncology; molecular pathology; sarcomas; solid tumors; RNA sequencing; DNA sequencing; epigenomics; multidisciplinary team; clinicopathological correlation

(This special issue belongs to the Section Molecular Oncology)

Advances in the Molecular Pathogenesis, Diagnosis and Treatment of Inherited Metabolic Diseases

edited by

Patryk Lipiński

submission deadline 28 Feb 2027 | Viewed by 27 | Submission Open

Keywords: inherited metabolic disease; inborn errors of metabolism; newborn screening; mitochondrial disorders; lysosomal storage diseases; congenital disorders of glycosylation; organic acidurias; amino acid disorders; fatty acid oxidation defects; peroxisomal disorders; urea cycle defects

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Computational Intelligence and Algorithmic Advances in Molecular Materials Science

edited by

Elena Sheka

submission deadline 28 Feb 2027 | Viewed by 27 | Submission Open

Keywords: molecular modeling; data-driven molecular simulation; molecular materials; computational intelligence; machine learning

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Biomarkers of Central Nervous System Diseases and Disorders: 2nd Edition

edited by

David Gurwitz

and