New Insight into Non-Coding RNAs (ncRNAs) in Human Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 March 2026) | Viewed by 287
Special Issue Editor
Interests: RNA biology; cancer; tumorigenesis; neurological development; noncoding RNA; brain development; neuronal; neuronal–glial; gliomas
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Special Issue Information
Dear Colleagues,
There are over 100,000 known lncRNA sequences, reported at an approximate 4:1 ratio compared to protein-coding genes. lncRNAs can be located either intergenically or intragenically and may be transcribed in both the sense and antisense directions. This positional diversity suggests a tight regulatory bottleneck within the spatial genomic context.
SLNCR is a remarkable long noncoding RNA (lncRNA) that has attracted significant research interest due to its unique biological roles, particularly in cancer. Its significance lies in its ability to function as a scaffold, bringing together diverse molecular machineries that regulate gene expression at both the transcriptional and post-transcriptional levels. This regulatory capacity is partly mediated by the direct interaction of SLNCR with the androgen receptor and estrogen receptor-a, underscoring its broad implications across several hormone-responsive cancers.
Furthermore, human studies have shown that elevated SLNCR expression is associated with improved overall survival in patients with ERa+ tumors. Given its central role in cancer progression, SLNCR represents an attractive target for therapeutic intervention.
Dr. Brian D. Adams
Guest Editor
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Keywords
- lncRNA
- therapy
- cancer
- SLNCR
- tumor suppressor
- SINE
- estrogen
- ERRL01
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