New Insight into Non-Coding RNAs (ncRNAs) in Human Research

Dear Colleagues,

There are over 100,000 known lncRNA sequences, reported at an approximate 4:1 ratio compared to protein-coding genes. lncRNAs can be located either intergenically or intragenically and may be transcribed in both the sense and antisense directions. This positional diversity suggests a tight regulatory bottleneck within the spatial genomic context.

SLNCR is a remarkable long noncoding RNA (lncRNA) that has attracted significant research interest due to its unique biological roles, particularly in cancer. Its significance lies in its ability to function as a scaffold, bringing together diverse molecular machineries that regulate gene expression at both the transcriptional and post-transcriptional levels. This regulatory capacity is partly mediated by the direct interaction of SLNCR with the androgen receptor and estrogen receptor-a, underscoring its broad implications across several hormone-responsive cancers.

Furthermore, human studies have shown that elevated SLNCR expression is associated with improved overall survival in patients with ERa+ tumors. Given its central role in cancer progression, SLNCR represents an attractive target for therapeutic intervention.

Dr. Brian D. Adams
Guest Editor

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