The Role of Non-coding RNAs in Neuronal Development and Neural Type Cancers

Dear Colleague,

Noncoding RNA is considered the “dark matter” of the genome, since scientists know little regarding the regulatory functions associated with these genetic elements. It is, however, evident that as this regulatory variation is uncovered, new and innovative medicines are being developed to treat some of the most difficult human diseases. One such group of neoplasms involves a complex series of tumors termed “neuronal” or “neuronal–glial”, which are of recent interest because, while benign compared to the more infiltrative gliomas and astrocytomas, they can serve as a comparative to help scientists to elucidate how noncoding RNAs initiate the tumorigenic process. Furthermore, these scientific investigations into the noncoding RNA world may lend further support into understanding the mechanisms that repress signaling pathways associative to invasiveness, migration, and metastasis. This Special Issue highlights ongoing research that provides substantial evidence for how these new noncoding genetic culprits involved in neuronal development can result in the alterations of cell fate choices, promoting neuronal–glial tumor progression versus glioma/astrocytoma development.

Dr. Brian D. Adams
Guest Editor

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• RNA
• miRNA
• RNA
• lncRNA
• noncoding RNA
• cancer
• development
• neurologic disorders
• neuronal differentiation