Molecular Research Advances in Metabolic Syndrome
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 572
Special Issue Editor
Interests: metabolic syndrome; obesity paradox; Chagas disease; nitric oxide; macrophages; eicosanoids; cytokines; immune response
Special Issue Information
Dear Colleagues,
Metabolic syndrome (MetS) is a multifactorial condition characterized by a constellation of risk factors—including central obesity, dyslipidemia, insulin resistance, and hypertension—which predispose individuals to cardiovascular diseases, type 2 diabetes, and increased susceptibility to infections. Emerging molecular research has revealed intricate links between MetS and sepsis, highlighting how chronic metabolic inflammation compromises immune responses. Intriguingly, the so-called “obesity paradox”—where obese patients sometimes exhibit better outcomes in acute illnesses such as sepsis—adds a layer of complexity to our understanding of metabolic–immune interactions. This Special Issue aims to gather high-quality studies that delve into the molecular mechanisms underlying MetS, with a focus on inflammation, mitochondrial dysfunction, immune–metabolic crosstalk, and therapeutic interventions. Both experimental (animal and cellular models) and clinical research studies are welcome. We encourage contributions that challenge conventional views and provide novel insights into the paradoxes and pathophysiology of MetS in diverse disease contexts.
Original research papers and comprehensive, up-to-date review articles are welcome.
I look forward to receiving your contributions.
Prof. Dr. Phileno Pinge-Filho
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
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Keywords
- metabolic syndrome
- sepsis
- molecular mechanisms
- inflammation
- insulin resistance
- cardiovascular parameters
- immune–metabolic crosstalk
- experimental models
- biomarkers
- therapeutic targets
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