The Stromal-Epithelial Dialogues in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3744
Special Issue Editor
Special Issue Information
Dear Colleagues,
As you know, epithelial tissues are the main interfaces between our inner body and the external world. Their renewal and integrity are crucial in order to preserve our body from damage generated by harmful substances and exposures. These highly specialized tissues are involved in diverse functions such as microbe protection, nutrients and water absorption, hormones and enzymes secretion, gas exchanges, etc. In order to assure their maintenance and multiple roles, epithelia are supported by the stroma that corresponds to the connective tissue whose main functions, in regard to the epithelia and aside from immunity, are mechanical (support) and metabolic (nutrition and various exchanges). The stroma is composed of a cellular compartment including fibroblasts, immune cells, vessels, nerves, and glial cells, and an acellular one, the extracellular matrix. In homeostasis, actors of both stromal compartments are active players in the regulation of the renewal, differentiation, integrity, and functions of epithelial tissues. Moreover, it is now well established that under pathological conditions (inflammation, metabolic disorders, and cancer), alteration of either the epithelial or the stromal tissue will immediately affect the other one.
This Special Issue focuses on the latest advances in understanding the stromal–epithelial dialogue involved in physiological and/or pathological contexts. We will address how it participates to cell fates, tissue architecture and remodeling, during the different steps of development, under homeostasis or disease status, and the cellular and molecular events involved.
Dr. Audrey Ferrand
Guest Editor
Manuscript Submission Information
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Keywords
- epithelial tissues
- epithelia
- stroma
- connective tissue
- immunity
- metabolic
