Stem Cells in Neurodegenerative Pathologies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 23811
Special Issue Editors
2. Neuroscience Center, HiLIFE, University of Helsinki, Helsinki, Finland
Interests: models of neurodegenerative diseases; schizophrenia and psychopathy; use of stem cells in neurodegeneration and neurodevelopment; blood-brain barrier; organ-on-chip; humanized models; identification of potential therapeutic molecules for brain diseases
Interests: neurodegeneration; mitochondrial function; inflammation; potassium channels
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are characterized by the chronic and progressive loss of neuronal functions in specific brain areas, resulting in memory deficit, cognitive impairment, or impaired motor coordination. There is a wide range of hereditary and sporadic neurologic disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. All these diseases occur as a result of neurodegeneration and include typical protein misfolding and aggregation. Although intensive efforts have been made to find a cure, effective treatments for neurodegenerative diseases have not yet been discovered. Possible reasons for this include the lack of appropriate human disease models and a limited understanding of the etiological and neurobiological mechanisms of these conditions. Experimental models that accurately mimic the development of neurodegenerative diseases in humans are desperately needed to understand the cause and mechanisms of these diseases, as well as to identify new therapeutic targets. Recent advances in stem cell technology have opened the path to the generation of induced pluripotent stem cells (iPSCs) from somatic cells, thus offering an unlimited source of patient-specific disease-relevant cells for more accurate modeling. In this Special Issue, we aim to summarize the current knowledge in this important field and give researchers the possibility of sharing novel data on the multiple aspects of modeling neurodegeneration by using stem cells in different disease pathologies. We invite experts to contribute with critical reviews and research papers on, but not limited to, the neurodegenerative diseases mentioned above, describing different models and mechanisms that play a role in neurodegeneration and the use of such models in drug discovery.
Dr. Šárka Lehtonen
Guest Editor
Dr. Amalia Dolga
Co-Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegenerative diseases
- stem cells
- cell-autonomous and non-cell-autonomous mechanism
- protein misfolding and aggregation
- inflammation
- humanized models
- drug discoveries
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
