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Skin Microbiome
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Skin Microbiome

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 11408

Special Issue Editor

Prof. Dr. Chun-Ming Huang

E-Mail
Guest Editor
1. Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 32001, Taiwan
2. Department of Dermatology, School of Medicine, University of California, San Diego, CA 92121, USA
Interests: skin microbiome; probiotic; vaccine; immunology; microbiology

Special Issue Information

Dear Colleagues,

Approximately one thousand species of microbes from nineteen phyla are present on human skin. The skin microbiome refers to the entire collection of skin microbes and their genomes and metabolomes, and has been a hot topic in healthcare, skincare, and even the big data analytics industry due to its significant impact on several aspects of human health. This Special Issue will present a collection of advanced studies on the skin microbiome. Authors are invited to contribute articles related to the following topics: skin microbiome analysis using genomic and metagenomic approaches, investigation of skin microbe–host interactions, examination of the underlying mechanisms of dysbiotic skin microbiome, identification of probiotics, prebiotics, and post-biotics derived from the skin microbiome, establishment of animal models for studying the skin microbiome, and clinical studies on the skin microbiome.

Prof. Dr. Chun-Ming Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Host-microbe interaction
  • Probiotic
  • Prebiotic
  • Microbiome
  • Skin microbiome
  • Skin diseases

Published Papers (2 papers)

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Research

11 pages, 1460 KiB  
Article
PEG-8 Laurate Fermentation of Staphylococcus epidermidis Reduces the Required Dose of Clindamycin Against Cutibacterium acnes
by Shinta Marito, Sunita Keshari and Chun-Ming Huang
Int. J. Mol. Sci. 2020, 21(14), 5103; https://doi.org/10.3390/ijms21145103 - 19 Jul 2020
Cited by 7 | Viewed by 3424
Abstract
The probiotic activity of skin Staphylococcus epidermidis (S. epidermidis) bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selectively induce the fermentation of S. epidermidis [...] Read more.
The probiotic activity of skin Staphylococcus epidermidis (S. epidermidis) bacteria can elicit diverse biological functions via the fermentation of various carbon sources. Here, we found that polyethylene glycol (PEG)-8 Laurate, a carbon-rich molecule, can selectively induce the fermentation of S. epidermidis, not Cutibacterium acnes (C. acnes), a bacterium associated with acne vulgaris. The PEG-8 Laurate fermentation of S. epidermidis remarkably diminished the growth of C. acnes and the C. acnes-induced production of pro-inflammatory macrophage-inflammatory protein 2 (MIP-2) cytokines in mice. Fermentation media enhanced the anti-C. acnes activity of a low dose (0.1%) clindamycin, a prescription antibiotic commonly used to treat acne vulgaris, in terms of the suppression of C. acnes colonization and MIP-2 production. Furthermore, PEG-8 Laurate fermentation of S. epidermidis boosted the activity of 0.1% clindamycin to reduce the sizes of C. acnes colonies. Our results demonstrated, for the first time, that the PEG-8 Laurate fermentation of S. epidermidis displayed the adjuvant effect on promoting the efficacy of low-dose clindamycin against C. acnes. Targeting C. acnes by lowering the required doses of antibiotics may avoid the risk of creating drug-resistant C. acnes and maintain the bacterial homeostasis in the skin microbiome, leading to a novel modality for the antibiotic treatment of acne vulgaris. Full article
(This article belongs to the Special Issue Skin Microbiome)
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12 pages, 7515 KiB  
Article
Lysates of a Probiotic, Lactobacillus rhamnosus, Can Improve Skin Barrier Function in a Reconstructed Human Epidermis Model
by Ye-On Jung, Haengdueng Jeong, Yejin Cho, Eun-Ok Lee, Hye-Won Jang, Jinwook Kim, Ki Taek Nam and Kyung-Min Lim
Int. J. Mol. Sci. 2019, 20(17), 4289; https://doi.org/10.3390/ijms20174289 - 02 Sep 2019
Cited by 40 | Viewed by 7428
Abstract
The main function of the skin is to protect the body from the external environment. The barrier function of the skin is mainly provided by the stratum corneum, which consists of corneocytes bound with the corneodesmosomes and lamellar lipids. Skin barrier proteins like [...] Read more.
The main function of the skin is to protect the body from the external environment. The barrier function of the skin is mainly provided by the stratum corneum, which consists of corneocytes bound with the corneodesmosomes and lamellar lipids. Skin barrier proteins like loricrin and filaggrin also contribute to the skin barrier function. In various skin diseases, skin barrier dysfunction is a common symptom, and skin irritants like detergents or surfactants could also perturb skin barrier function. Many efforts have been made to develop strategies to improve skin barrier function. Here, we investigated whether the microfluidized lysates of Lactobacillus rhamnosus (LR), one of the most widely used probiotic species for various health benefits, may improve the skin barrier function in a reconstructed human epidermis, Keraskin™. Application of LR lysate on Keraskin™ increased the expression of tight junction proteins; claudin 1 and occludin as determined by immunofluorescence analysis, and skin barrier proteins; loricrin and filaggrin as determined by immunohistochemistry and immunofluorescence analysis and qPCR. Also, the cytotoxicity of a skin irritant, sodium lauryl sulfate (SLS), was alleviated by the pretreatment of LR lysate. The skin barrier protective effects of LR lysate could be further demonstrated by the attenuation of SLS-enhanced dye-penetration. LR lysate also attenuated the destruction of desmosomes after SLS treatment. Collectively, we demonstrated that LR lysate has protective effects on the skin barrier, which could expand the utility of probiotics to skin-moisturization ingredients. Full article
(This article belongs to the Special Issue Skin Microbiome)
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