Molecular Biology of 3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 June 2026 | Viewed by 778
Special Issue Editor
Interests: oxidative stress and damage (OSaD); inflammation; regenerative medicine; neural stem cell networks; 3D cell and tissue physiology; tissue toxicity; high-energy and galactic cosmic radiation impacts; environmental toxins; genomic/proteomic cellular responses
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Three-dimensional (3D) biology dates back over 110 years to the pioneering work of the French surgeon and researcher Alexis Carrel, who won the Nobel Prize in Physiology in 1912. His work encompassed unique and innovative applications in tissue and cell culturing, with his focus directed toward anastomosis and revolutionary suturing techniques. To date, this field has rapidly metamorphosized, encompassing a wide variety of applications.
This Special Issue will welcome manuscripts that explore the many evolving benefits of 3D physiological systems biology as compared to standard 2D culture systems in research and preclinical arenas. These include, but are not limited to, microgravity-related applications, cellular and molecular outcomes (omics), cellular and tissue toxicity, drug discovery applications, 3D tissues as viral research and discovery targets, and 3D tissue engineering in the context of potential transplantation, regenerative medicine (stem cells and regeneration), and bioprinting applications. In the arena of “omics”, we invite the submission of manuscripts which address, but are not limited to, genomics, proteomics, metabolomics, transcriptomics, and the spatial biology of 3D physiological systems. Manuscripts addressing the challenges of developing authentic tissue “mimics” with regard to functional accuracy and structural recapitulation will also be considered favourably.
Dr. Thomas J. Goodwin
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- 3D physiological relevance vs. 2D biology, 3D research, and diagnostic systems
- evolving 3D “omics” applications
- research and clinical medicine
- drug applications
- toxicity evaluations
- “Omics”
- spatial biology of 3D
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
