Special Issue "Protein Machines Acting on DNA: Structure, Dynamics and Functional Mechanisms"
Deadline for manuscript submissions: closed (31 March 2021).
The interaction between individual proteins and multi-protein complexes with DNA sequences is crucial for cell survival across all domains of life. These interactions are involved in a range of processes including DNA condensation, transcription, replication and repair and have received considerable attention due to their biological relevance. Over the last decade, our understanding of how these protein machineries physically interact with the nucleic acid structure to preserve DNA integrity, regulate its expression and resolve damaged sequences has progressed enormously. These advances have taken place at all mechanistic steps in which such interactions can be dissected: nucleic acid recognition, assembly, conformational reorganization, recruitment of additional partners and chemical catalysis. Such progress has been facilitated by parallel breakthroughs in many areas including DNA sequencing technologies to map interactions across the genome, cryo-EM methods to unveil structures of difficult-to-crystallize macro-complexes, more versatile site-specific tagging and cross-linking strategies, and the ability to detect low-populated transient states with sub-millisecond resolution at single-molecule level. As a result, molecular-level information regarding protein diffussion along the genome, dynamic assembly of these complexes and enzymatic aspects has never been so detailed both in vitro and in vivo. Moreover, the ability to edit specific DNA sequences, with unprecedented simplicity, using CRISPR-based technologies opens a new era to investigate genome-based functionality and anomalies. Articles in this special issue should focus on structural aspects and/or kinetic insights regarding the functional mechanisms of protein-DNA interactions. Papers providing molecular-level information or techniques enabling this would be of special interest.
Dr. Carlos Penedo
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- Nucleic acids recognition and processing
- Structure determination by Cryo-EM/X-ray
- Dynamics of protein-DNA complexes in vivo and in vitro
- DNA replication
- DNA transcription
- DNA repair
- DNA recombination