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Special Issue "Mechanisms and Therapeutics of Platelet Thrombus Formation"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (25 September 2019).
Special Issues and Collections in MDPI journals
Platelets are normally free flowing in a blood vessel. However, in the event of vessel injury or disease such as atherosclerotic plaques, platelets will initially tether, via exposed extracellular matrix ligands with respective platelet receptors, then adhesive events occur, followed by activation through signaling events. These inside out signaling events lead to the conversion of the major platelet integrin alphaIIbbeta3 from a resting to an activated state, where it will bind its natural ligands, including fibrinogen, to create stable platelet aggregates. The numerous steps involved in platelet thrombus formation are regulated by different receptors, ligands, signaling molecules, rheological biomechanical forces, and soluble agonist dependent mechanisms. These events regulate not only thrombus growth and stability but also the propagation of blood clots formed. In addition, papers that evaluate new technologies or new therapeutics that modulate thrombus formation will be also be considered.
Prof. Dr. Denise Jackson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- platelet adhesion
- platelet aggregation
- tissue factor bearing microparticles
- thrombus growth
- thrombus stability
- platelet tethering
- platelet activation
- propagation of thrombus formation
- rheological biomechanical platelet aggregation
- soluble agonist dependent mechanisms