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Potential Mechanisms of Muscle Mitochondrial Dysfunction in Aging and Obesity and Cellular Consequences

1
INRA, UMR1019 Nutrition Humaine, F-63120 Saint Genès Champanelle, France
2
Université Clermont 1, UFR Médecine, UMR1019 Nutrition Humaine, F-63000 Clermont-Ferrand, France
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Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2009, 10(1), 306-324; https://doi.org/10.3390/ijms10010306
Received: 10 October 2008 / Revised: 7 January 2009 / Accepted: 9 January 2009 / Published: 13 January 2009
(This article belongs to the Special Issue Molecular System Bioenergetics)
Mitochondria play a key role in the energy metabolism in skeletal muscle. A new concept has emerged suggesting that impaired mitochondrial oxidative capacity in skeletal muscle may be the underlying defect that causes insulin resistance. According to current knowledge, the causes and the underlying molecular mechanisms at the origin of decreased mitochondrial oxidative capacity in skeletal muscle still remain to be elucidated. The present review focuses on recent data investigating these issues in the area of metabolic disorders and describes the potential causes, mechanisms and consequences of mitochondrial dysfunction in the skeletal muscle. View Full-Text
Keywords: Mitochondrial dysfunction; skeletal muscle; metabolic disorders; obesity; insulin resistance; type 2 diabetes Mitochondrial dysfunction; skeletal muscle; metabolic disorders; obesity; insulin resistance; type 2 diabetes
MDPI and ACS Style

Chanséaume, E.; Morio, B. Potential Mechanisms of Muscle Mitochondrial Dysfunction in Aging and Obesity and Cellular Consequences. Int. J. Mol. Sci. 2009, 10, 306-324.

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