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Special Issue "Molecular Pathophysiology, Diagnostics, and Therapeutics in Common Neonatal and Pediatric Diseases"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 March 2021.

Special Issue Editor

Dr. Ichiro Morioka
Website
Guest Editor
Nihon University School of Medicine, Tokyo, Japan
Interests: pediatrics; neonatology

Special Issue Information

Dear Colleagues,

In recent years, the development of molecular biological and genetic medical technologies has been remarkable, many pediatric intractable diseases and rare diseases have been diagnosed, and therapeutic methods have been developed. Meanwhile, when we look at common neonatal and pediatric diseases, conventional diagnostic and therapeutic methods are still often used to this day. It is also necessary to apply innovative thinking, science, and technology to common neonatal and pediatric diseases in order to elucidate their pathophysiology and develop novel diagnosis methods and treatments.

In this special issue, more focused area is the common diseases associated with preterm and term infants, such as neonatal jaundice and neonatal infection, and common growth disorders that are strongly influenced by the conditions during the neonatal period, such as short children born small-for gestational age and pediatric non-communicable diseases (metabolic syndrome, obesity, diabetes, hypertension, and hyperlipidemia).

Dr. Ichiro Morioka
Guest Editor

Manuscript Submission Information

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Keywords

  • common diseases
  • pediatric and neonatal patients
  • innovative thinking
  • novel diagnostic and therapeutic methods
  • neonatal jaundice
  • neonatal infection
  • short children born small-for gestational age
  • pediatric metabolic syndrome
  • obesity
  • diabetes
  • hypertension
  • hyperlipidemia

Published Papers (1 paper)

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Research

Open AccessArticle
A Novel Method for Measuring Serum Unbound Bilirubin Levels Using Glucose Oxidase–Peroxidase and Bilirubin-Inducible Fluorescent Protein (UnaG): No Influence of Direct Bilirubin
Int. J. Mol. Sci. 2020, 21(18), 6778; https://doi.org/10.3390/ijms21186778 - 16 Sep 2020
Abstract
The glucose oxidase–peroxidase (GOD–POD) method used to measure serum unbound bilirubin (UB) suffers from direct bilirubin (DB) interference. Using a bilirubin-inducible fluorescent protein from eel muscle (UnaG), a novel GOD–POD–UnaG method for measuring UB was developed. Newborn sera with an indirect bilirubin/albumin (iDB/A) [...] Read more.
The glucose oxidase–peroxidase (GOD–POD) method used to measure serum unbound bilirubin (UB) suffers from direct bilirubin (DB) interference. Using a bilirubin-inducible fluorescent protein from eel muscle (UnaG), a novel GOD–POD–UnaG method for measuring UB was developed. Newborn sera with an indirect bilirubin/albumin (iDB/A) molar ratio of <0.5 were classified into four groups of DB/total serum bilirubin (TB) ratios (<5%, 5–10%, 10–20%, and ≥20%), and the correlation between the UB levels and iDB/A ratio was examined. Linear regression analysis was performed to compare UB values from both methods with the iDB/A ratio from 38 sera samples with DB/TB ratio <5% and 11 samples with DB/TB ratio ≥5%. The correlation coefficient (r) between UB values and the iDB/A ratio for the GOD–POD method was 0.8096 (DB/TB ratio <5%, n = 239), 0.7265 (5–10%, n = 29), 0.7165 (10–20%, n = 17), and 0.4816 (≥20%, n = 16). UB values using the GOD–POD–UnaG method highly correlated with the iDB/A ratio in both <5% and ≥5% DB/TB ratio sera (r = 0.887 and 0.806, respectively), whereas a low correlation (r = 0.428) occurred for ≥5% DB/TB ratio sera using the GOD–POD method. Our GOD–POD–UnaG method can measure UB levels regardless of the presence of DB. Full article
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