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Molecular Pathophysiology, Diagnostics, and Therapeutics in Common Neonatal and Pediatric...
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Molecular Pathophysiology, Diagnostics, and Therapeutics in Common Neonatal and Pediatric Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 2722

Special Issue Editor

Prof. Dr. Ichiro Morioka

E-Mail Website
Guest Editor
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 113-8602, Japan
Interests: pediatrics; neonatology; cytomegalovirus; toxoplasma; mother-to-child infection
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the development of molecular biological and genetic medical technologies has been remarkable, many pediatric intractable diseases and rare diseases have been diagnosed, and therapeutic methods have been developed. Meanwhile, when we look at common neonatal and pediatric diseases, conventional diagnostic and therapeutic methods are still often used to this day. It is also necessary to apply innovative thinking, science, and technology to common neonatal and pediatric diseases in order to elucidate their pathophysiology and develop novel diagnosis methods and treatments.

In this special issue, more focused area is the common diseases associated with preterm and term infants, such as neonatal jaundice and neonatal infection, and common growth disorders that are strongly influenced by the conditions during the neonatal period, such as short children born small-for gestational age and pediatric non-communicable diseases (metabolic syndrome, obesity, diabetes, hypertension, and hyperlipidemia).

Dr. Ichiro Morioka
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • common diseases
  • pediatric and neonatal patients
  • innovative thinking
  • novel diagnostic and therapeutic methods
  • neonatal jaundice
  • neonatal infection
  • short children born small-for gestational age
  • pediatric metabolic syndrome
  • obesity
  • diabetes
  • hypertension
  • hyperlipidemia

Published Papers (1 paper)

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Research

11 pages, 1675 KiB  
Article
A Novel Method for Measuring Serum Unbound Bilirubin Levels Using Glucose Oxidase–Peroxidase and Bilirubin-Inducible Fluorescent Protein (UnaG): No Influence of Direct Bilirubin
by Sota Iwatani, Keiji Yamana, Hajime Nakamura, Kosuke Nishida, Takeshi Morisawa, Masami Mizobuchi, Kayo Osawa, Kazumoto Iijima and Ichiro Morioka
Int. J. Mol. Sci. 2020, 21(18), 6778; https://doi.org/10.3390/ijms21186778 - 16 Sep 2020
Cited by 10 | Viewed by 2367
Abstract
The glucose oxidase–peroxidase (GOD–POD) method used to measure serum unbound bilirubin (UB) suffers from direct bilirubin (DB) interference. Using a bilirubin-inducible fluorescent protein from eel muscle (UnaG), a novel GOD–POD–UnaG method for measuring UB was developed. Newborn sera with an indirect bilirubin/albumin (iDB/A) [...] Read more.
The glucose oxidase–peroxidase (GOD–POD) method used to measure serum unbound bilirubin (UB) suffers from direct bilirubin (DB) interference. Using a bilirubin-inducible fluorescent protein from eel muscle (UnaG), a novel GOD–POD–UnaG method for measuring UB was developed. Newborn sera with an indirect bilirubin/albumin (iDB/A) molar ratio of <0.5 were classified into four groups of DB/total serum bilirubin (TB) ratios (<5%, 5–10%, 10–20%, and ≥20%), and the correlation between the UB levels and iDB/A ratio was examined. Linear regression analysis was performed to compare UB values from both methods with the iDB/A ratio from 38 sera samples with DB/TB ratio <5% and 11 samples with DB/TB ratio ≥5%. The correlation coefficient (r) between UB values and the iDB/A ratio for the GOD–POD method was 0.8096 (DB/TB ratio <5%, n = 239), 0.7265 (5–10%, n = 29), 0.7165 (10–20%, n = 17), and 0.4816 (≥20%, n = 16). UB values using the GOD–POD–UnaG method highly correlated with the iDB/A ratio in both <5% and ≥5% DB/TB ratio sera (r = 0.887 and 0.806, respectively), whereas a low correlation (r = 0.428) occurred for ≥5% DB/TB ratio sera using the GOD–POD method. Our GOD–POD–UnaG method can measure UB levels regardless of the presence of DB. Full article
(This article belongs to the Special Issue Molecular Pathophysiology, Diagnostics, and Therapeutics in Common Neonatal and Pediatric Diseases)
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