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Molecular Studies of Glioblastoma
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Molecular Studies of Glioblastoma

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 May 2023) | Viewed by 4503

Special Issue Editors

Dr. Wei-Hsiu Liu

E-Mail Website
Guest Editor
Department of Neurological Surgery, Tri-Service General Hospital and National Defense Medical Center, Taipei 114, Taiwan
Interests: cancer stem cells; tumor motility; chemoresistance and radioresistance of glioma
Dr. Hsin-I Ma

E-Mail Website
Guest Editor
Department of Neurological Surgery, Tri-Service General Hospital and National Defense Medical Center, Taipei 114, Taiwan
Interests: brain tumorigenesis; inflammation and autophagy of glioma

Special Issue Information

Dear Colleagues,

Glioblastoma is one of the most aggressive tumors and the deadliest among brain tumors, with a 5-year survival rate of only 4.6 percent. Although people are doing their best to unravel the complexity of this tumor, efforts still fall short of expectations. Therefore, in-depth study of the potential molecular mechanism of glioblastoma, looking for new treatment targets, and improving the survival rate of patients is still a top priority. This includes, but is not limited to, the signal transduction pathways, energy metabolic requirements, genetic and epigenetic characteristics of glioblastoma formation and development, the interactions between glioma cells and their microenvironments (immune cells, blood vessels or neurons/gliocytes), and the signaling mechanisms involved in these interactions.

This Special Issue will focus on reviews, comments and research papers on the molecular mechanisms of glioblastoma. It is necessary to have more in-depth insight into the molecular changes in glioblastoma, and these findings are likely to provide useful information for the design of treatments to improve the survival rate of patients.

Kind regards,

Dr. Wei-Hsiu Liu
Dr. Hsin-I Ma
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioblastoma
  • molecular mechanism
  • tumorigenesis
  • glioblastoma-stem-like cells
  • tumor motiltiy
  • inflammation
  • autophagy

Published Papers (2 papers)

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Research

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23 pages, 44863 KiB  
Article
The Comparative Experimental Study of Sodium and Magnesium Dichloroacetate Effects on Pediatric PBT24 and SF8628 Cell Glioblastoma Tumors Using a Chicken Embryo Chorioallantoic Membrane Model and on Cells In Vitro
by Eligija Damanskienė, Ingrida Balnytė, Angelija Valančiūtė, Vaiva Lesauskaitė, Marta Marija Alonso and Donatas Stakišaitis
Int. J. Mol. Sci. 2022, 23(18), 10455; https://doi.org/10.3390/ijms231810455 - 09 Sep 2022
Cited by 3 | Viewed by 1656
Abstract
In this study, pyruvate dehydrogenase kinase-1 inhibition with dichloroacetate (DCA) was explored as an alternative cancer therapy. The study’s aim was to compare the effectiveness of NaDCA and MgDCA on pediatric glioblastoma PBT24 and SF8628 tumors and cells. The treatment effects were evaluated [...] Read more.
In this study, pyruvate dehydrogenase kinase-1 inhibition with dichloroacetate (DCA) was explored as an alternative cancer therapy. The study’s aim was to compare the effectiveness of NaDCA and MgDCA on pediatric glioblastoma PBT24 and SF8628 tumors and cells. The treatment effects were evaluated on xenografts growth on a chicken embryo chorioallantoic membrane. The PCNA, EZH2, p53, survivin expression in tumor, and the SLC12A2, SLC12A5, SLC5A8, CDH1, and CDH2 expression in cells were studied. The tumor groups were: control, cells treated with 10 mM and 5 mM of NaDCA, and 5 mM and 2.5 mM of MgDCA. The cells were also treated with 3 mM DCA. Both the 10 mM DCA preparations significantly reduced PBT24 and SF8624 tumor invasion rates, while 5 mM NaDCA reduced it only in the SF8628 tumors. The 5 mM MgDCA inhibited tumor-associated neoangiogenesis in PBT24; both doses of NaDCA inhibited tumor-associated neoangiogenesis in SF8628. The 10 mM DCA inhibited the expression of markers tested in PBT24 and SF8628 tumors, but the 5 mM DCA affect on their expression depended on the cation. The DCA treatment did not affect the SLC12A2, SLC12A5, and SLC5A8 expression in cells but increased CDH1 expression in SF8628. The tumor response to DCA at different doses indicated that a contrast between NaDCA and MgDCA effectiveness reflects the differences in the tested cells’ biologies. Full article
(This article belongs to the Special Issue Molecular Studies of Glioblastoma)
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Review

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20 pages, 1263 KiB  
Review
Post-Transcriptional Modifications of RNA as Regulators of Apoptosis in Glioblastoma
by Anton Dome, Maya Dymova, Vladimir Richter and Grigory Stepanov
Int. J. Mol. Sci. 2022, 23(16), 9272; https://doi.org/10.3390/ijms23169272 - 17 Aug 2022
Cited by 6 | Viewed by 2167
Abstract
This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, [...] Read more.
This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, associated with the process of apoptosis, presents data on the features of apoptosis in glioblastoma cells, and shows the relationship between regulatory RNAs and the apoptosis in tumor cells. In conclusion, potential target candidates are presented that are necessary for the development of new drugs for the treatment of glioblastoma. Full article
(This article belongs to the Special Issue Molecular Studies of Glioblastoma)
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