Special Issue "Metabolic Associated Fatty Liver Disease: A New Definition"
Deadline for manuscript submissions: closed (30 November 2021).
2. Japan Strategic Medical Administration Research Center (J-SMARC), Nagoya, Aichi, Japan
Interests: Interests: nonalcoholic steatohepatitis; oxidative stress; hepatic fibrosis; diabetes mellitus; liver cirrhosis; hepatocellular carcinoma
Worldwide, 25% of the adult population suffers from nonalcoholic fatty liver disease (NAFLD). Until now, the exclusion of other chronic liver diseases including "excess" alcohol intake has been necessary to establish a diagnosis of NAFLD. Recently, a consensus of international experts proposed that the disease acronym be changed from NAFLD to metabolic (dysfunction)-associated fatty liver disease (MAFLD). The diagnostic criteria of MAFLD are based on evidence of hepatic steatosis, in addition to one of the following three criteria, namely overweight/obesity, presence of type 2 diabetes, or evidence of metabolic dysregulation. MAFLD is a novel concept proposed in 2020, the utility of which has not been tested and validated in the real world. MAFLD can coexist with other liver diseases. Therefore, MAFLD plus a hepatitis B virus (HBV) inactive carrier, MAFLD plus alcoholic liver disease (ALD), MAFLD plus autoimmune hepatitis (AIH), or MAFLD plus drug-induced liver injury (DILI) are plausible as a final diagnosis in clinical practice. MAFLD definition is more practical for identifying patients with fatty liver disease with a high risk of disease progression. This Special Issue will include papers investigating the pathological mechanisms, diagnostics using new biomarkers, and treatment strategies in MAFLD. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate MAFLD are welcome. This Special Issue welcomes original research and review papers regarding MAFLD.
Dr. Yoshio Sumida
Manuscript Submission Information
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- • Nonalcoholic fatty liver disease
- • Metabolism-associated fatty liver disease
- • Hepatocellular carcinoma
- • Type 2 diabetes
- • Hepatic fibrosis
- • Liver cirrhosis
- • PNPLA3
- • Obesity
- • Metabolic syndrome