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Special Issue "Metabolic Associated Fatty Liver Disease: A New Definition"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 28 February 2021.

Special Issue Editor

Dr. Yoshio Sumida
Website1 Website2
Guest Editor
1. Department of Hepatology and Pancreatology, Aichi Medical University of Medicine, Nagakute, Aichi, Japan;
2. Japan Strategic Medical Administration Research Center (J-SMARC), Nagoya, Aichi, Japan
Interests: Interests: nonalcoholic steatohepatitis; oxidative stress; hepatic fibrosis; diabetes mellitus; liver cirrhosis; hepatocellular carcinoma

Special Issue Information

Dear Colleagues,

Worldwide, 25% of the adult population suffers from nonalcoholic fatty liver disease (NAFLD). Until now, the exclusion of other chronic liver diseases including "excess" alcohol intake has been necessary to establish a diagnosis of NAFLD. Recently, a consensus of international experts proposed that the disease acronym be changed from NAFLD to metabolic (dysfunction)-associated fatty liver disease (MAFLD). The diagnostic criteria of MAFLD are based on evidence of hepatic steatosis, in addition to one of the following three criteria, namely overweight/obesity, presence of type 2 diabetes, or evidence of metabolic dysregulation. MAFLD is a novel concept proposed in 2020, the utility of which has not been tested and validated in the real world. MAFLD can coexist with other liver diseases. Therefore, MAFLD plus a hepatitis B virus (HBV) inactive carrier, MAFLD plus alcoholic liver disease (ALD), MAFLD plus autoimmune hepatitis (AIH), or MAFLD plus drug-induced liver injury (DILI) are plausible as a final diagnosis in clinical practice. MAFLD definition is more practical for identifying patients with fatty liver disease with a high risk of disease progression. This Special Issue will include papers investigating the pathological mechanisms, diagnostics using new biomarkers, and treatment strategies in MAFLD. Furthermore, experimental in vitro and in vivo studies examining potential new approaches to attenuate MAFLD are welcome. This Special Issue welcomes original research and review papers regarding MAFLD.

Dr. Yoshio Sumida
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • • Nonalcoholic fatty liver disease
  • • Metabolism-associated fatty liver disease
  • • Hepatocellular carcinoma
  • • Type 2 diabetes
  • • Hepatic fibrosis
  • • Liver cirrhosis
  • • PNPLA3
  • • Obesity
  • • Metabolic syndrome

Published Papers

This special issue is now open for submission.
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