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Selected Papers from the 1st RNA and RNase International Meeting and Related Research

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (20 April 2026) | Viewed by 1086

Special Issue Editor


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Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Spain
Interests: host–pathogen interactions; antimicrobial peptides; enzymology; ribo-nucleases; innate immunity; structural biology; drug design
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Special Issue Information

Dear Colleagues,

We are currently organizing the First International Meeting on RNA and RNase, which will be held in Barcelona from 3rd to 4th July 2025 (https://webs.uab.cat/rna-rnase-meeting/). We invite researchers working at the RNA/RNase interface to participate in person or virtually.

This project aims to bridge the realms of nucleic acids and proteins and promote discoveries at an interdisciplinary level. The birth of biochemistry at the beginning of the 20th century is closely related to RNases, from the first 3D structures to the first catalytic mechanism. Now, in the 21st century, we are witnessing the emergence of RNA protagonism. A myriad of novel types of non-coding RNAs populate an expanding new world. To explore this newly discovered RNA landscape, we cannot disregard the presence of RNases and their trimming activities.

This Special Issue will focus on the RNase–RNA encounters that rule cell biology, covering topics from basic science to therapeutics. As a taster, here are some open questions for discussion: i) What are the structural bases for RNA recognition by RNases? ii) How do post-transcriptional modifications govern RNA processing? iii) How do RNAs work as intercellular communicators? iv) Are small RNAs good diagnosis markers? v) How can we engineer novel RNase-based drugs?

We would like to acknowledge Dr. Jiarui Li (Universitat Autònoma de Barcelona) for her participation as Guest Editor Assistant in the development of this Special Issue.

Prof. Dr. Ester Boix
Guest Editor

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Keywords

  • RNA
  • RNase
  • diagnosis markers
  • drug design
  • cell signalling
  • immunology
  • infection
  • cancer
  • structural biology
  • RNA binding proteins
  • RNA recognition patterns
  • RNA catalysis

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Published Papers (1 paper)

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Research

23 pages, 42731 KB  
Article
A Novel Method to Monitor the Evolution of Antimicrobial Resistance in Acinetobacter baumannii Biofilms
by Raul Anguita, Jiarui Li, Ester Boix and Guillem Prats-Ejarque
Int. J. Mol. Sci. 2026, 27(3), 1512; https://doi.org/10.3390/ijms27031512 - 3 Feb 2026
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Abstract
Biofilms are microbial communities embedded in an extracellular matrix that facilitates their attachment to surfaces. This lifestyle provides advantages to pathogenic bacteria, including increased survival in the presence of antibiotics and an enhanced capacity to develop resistance. Once a biofilm is established, infections [...] Read more.
Biofilms are microbial communities embedded in an extracellular matrix that facilitates their attachment to surfaces. This lifestyle provides advantages to pathogenic bacteria, including increased survival in the presence of antibiotics and an enhanced capacity to develop resistance. Once a biofilm is established, infections get difficult to eradicate and frequently become chronic. There is, therefore, an urgent need to develop novel strategies to counteract biofilm-associated antibiotic resistance. Here, we developed a method to monitor the evolution of antimicrobial resistance, aiming to evaluate novel drugs against bacterial resistance to antibiotics. We validated this methodology using an RNase chimera with antibiofilm activity and a reported ability to hinder colistin resistance in planktonic cultures of Acinetobacter baumannii (A. baumannii). We assessed the emergence of resistance in A. baumannii biofilms by repeated cycles of colistin exposure. This method not only preserves biofilm structure throughout treatment but also enables controlled induction of resistance acquisition while monitoring antimicrobial efficacy. Although the RNase enhanced the antibiotic’s activity against biofilms by reducing by 50% the effective dose, it did not prevent the emergence of colistin resistance, indicating that the protein may use distinct mechanisms against planktonic and biofilm communities. Nonetheless, our findings highlight the potential of this methodology for evaluating antibiotic-adjuvant candidates to combat antibiotic resistance in biofilms. Full article
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