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Autoimmune Diseases: A Swing Dance of Immune Cells, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 20 December 2026 | Viewed by 1037

Special Issue Editor

Special Issue Information

Dear Colleagues,

The human body constantly interacts with other organisms and with the environment. Such interactions allow the body to recognize beneficial influences from harmful influences, as well as what is its own and what is foreign. This is achieved through the immune system, which is a complex network of specialized cells and organs. Therefore, immune system cells are in a continuous "dance with different partners". The frequent "switching of partners" can lead to the immune system being unable to distinguish between self and non-self, which can initiate the development of autoimmune diseases. There are more than 80 known autoimmune diseases, some of which are more common and well studied (such as rheumatoid arthritis, multiple sclerosis, type 1 diabetes, and lupus), although others are rare. Interestingly, the etiology of most autoimmune diseases remains a mystery.

In this Special Issue, the key word is "change", i.e., changes in key molecules during disease-versus-normal states. We discuss changes in antigens, molecular interactions, antibody production, cell signaling, or tissue/organ structures that are associated with the initiation, development, or progression of autoimmune diseases. The development of therapeutic agents that target signaling pathways and lead to changes in T-cell or humoral immune responses will also be considered.

More published papers could be found in the closed Special Issues: Autoimmune Diseases: A Swing Dance of the Immune Cells and Autoimmune Diseases: A Swing Dance of Immune Cells, 2nd Edition

Prof. Dr. Balik Dzhambazov
Guest Editor

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Keywords

  • autoimmune diseases
  • antigens/autoantigens
  • post-translational modifications
  • antigen processing and presentation
  • shared epitopes
  • molecular mimicry
  • autoantibodies
  • immune signaling
  • animal models
  • therapeutic agents

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Published Papers (1 paper)

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Research

12 pages, 1301 KB  
Article
Establishment of Autoreactive CD4+CD8+ T Cell Hybridomas from Sjögren’s Disease Model, SATB1 Conditional Knockout Mice
by Shuhei Mashimo, Michitsune Arita, Taku Kuwabara, Taku Naito, Sakurako Takizawa, Akiko Inoue, Akira Ishiko, Motonari Kondo and Yuriko Tanaka
Int. J. Mol. Sci. 2026, 27(1), 414; https://doi.org/10.3390/ijms27010414 - 30 Dec 2025
Viewed by 761
Abstract
Sjögren’s disease (SjD), which is also known as Sjögren’s syndrome (SS), is a chronic autoimmune disease characterized by dysfunction of exocrine glands, such as the salivary and lacrimal glands, resulting in xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Mice in which the [...] Read more.
Sjögren’s disease (SjD), which is also known as Sjögren’s syndrome (SS), is a chronic autoimmune disease characterized by dysfunction of exocrine glands, such as the salivary and lacrimal glands, resulting in xerostomia (dry mouth) and keratoconjunctivitis sicca (dry eyes). Mice in which the SATB1 gene is conditionally deleted in hematopoietic cells (SATB1cKO mice) develop SS as early as 4 weeks of age; however, the etiology of the disease remains to be elucidated. Here, we found that the frequency of abnormally appearing CD4+CD8+ double positive (DP) T cells in the periphery of SATB1cKO mice was higher in the salivary glands than that in the spleen, suggesting a possible involvement of DP T cells in the pathogenesis of SS in SATB1cKO mice. To investigate the nature of DP T cells, we established DP T cell hybridomas by fusing T cells from the cervical lymph nodes of SATB1cKO mice with the BW5147 thymoma cell line. Among six DP hybridoma clones, the TCRβ gene from five clones exhibited a fetal or immature phenotype. In addition, four out of five clones exhibited upregulated transcription of IL-2 in the salivary glands of T/B cell-deficient RAG2−/− mice, suggesting that autoreactive T cells were enriched in the DP T cell population of SATB1cKO mice. These results suggest that unusual DP T cells in SATB1cKO mice may be involved in autoimmune pathogenesis in SATB1cKO mice. Full article
(This article belongs to the Special Issue Autoimmune Diseases: A Swing Dance of Immune Cells, 3rd Edition)
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