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Special Issue "Mechanisms of Hair Morphology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 May 2020.

Special Issue Editor

Prof. Kazumasa Wakamatsu
E-Mail Website
Guest Editor
Department of Chemistry, Fujita Health University School of Medical Sciences, Toyoake, Aichi 470-1192, Japan
Interests: UV damage; biosynthesis of melanin pathway; internal and external melanin; melanoma; fossil melanin; pro-oxidant activity

Special Issue Information

Dear Colleagues,

Hair on mammals has a unique character and several functions, from protection of skin to sexual and social communication. The psychological impact on quality of life caused by hair disorders, such as hirsutism, hair loss, etc., can be quite significant. A significantly higher prevalence of personality disorders in subjects with androgenetic alopecia compared with the prevalence of such diagnoses in the general population has been discovered. Mammalian skin produces hair almost all over the body surface, except for a few areas of the body, i.e., the soles of the feet, palms of the hands, buccal surface of the lip, and portions of external genitalia, whereas hair in other areas, such as the scalp, eyelashes, and eyebrows, is longer, thicker, and heavily pigmented. Differences are also related to the hair’s form, which can be straight, helical, or wavy. The color is dependent on the balance of quality and quantity of melanin (brown to black—indolic eumelanin and yellow to reddish brown—sulfur-containing pheomelanin). Human hair is usually classified according to three conventional ethnic human subgroups, i.e., African, Asian, and European. Nevertheless, a recent study showed that it is possible to classify the various hairs found worldwide into eight main coherent hair types by the measurement of three easily accessible parameters: curve diameter, curl index, and number of waves. Several studies on human hair have been conducted within many fields of science, including biology, dermatology, cosmetics, forensic sciences, and medicine. For this Special Issue of IJMS, we are looking for articles that can deliver a profound insight into the mechanism of hair morphology with respect to the principal anatomical and physiological aspects of the different types of mammalian hair; the molecular structure of hair; the immunology of hair follicles; the classification of hair; clinical observations of human hair, including aging; hormonal effects on hair follicles; and diagnostic use to consider the clinical and basic significance of the different structures and distribution of hair in the mammalian body.

Prof. Kazumasa Wakamatsu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • eumelanin
  • pheomelanin
  • anatomical structure
  • aging
  • cosmetics
  • forensic science
  • hair follicles
  • classification of hair
  • molecular structure of hair
  • immunology of follicles

Published Papers (1 paper)

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Open AccessReview
Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review
Int. J. Mol. Sci. 2020, 21(2), 523; https://doi.org/10.3390/ijms21020523 - 14 Jan 2020
Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and [...] Read more.
Hair loss is a disorder in which the hair falls out from skin areas such as the scalp and the body. Several studies suggest the use of herbal medicine to treat related disorders, including alopecia. Dermal microcirculation is essential for hair maintenance, and an insufficient blood supply can lead to hair follicles (HF) diseases. This work aims to provide an insight into the ethnohistorical records of some nutritional compounds containing flavonoids for their potential beneficial features in repairing or recovering from hair follicle disruption. We started from a query for “alopecia” OR “hair loss” AND “Panax ginseng C.A. Mey.“ (or other six botanicals) terms included in Pubmed and Web of Sciences articles. The activities of seven common botanicals introduced with diet (Panax ginseng C.A. Mey., Malus pumila Mill cultivar Annurca, Coffea arabica, Allium sativum L., Camellia sinensis (L.) Kuntze, Rosmarinum officinalis L., Capsicum annum L.) are discussed, which are believed to reduce the rate of hair loss or stimulate new hair growth. In this review, we pay our attention on the molecular mechanisms underlying the bioactivity of the aforementioned nutritional compounds in vivo, ex vivo and in vitro studies. There is a need for systematic evaluation of the most commonly used plants to confirm their anti-hair loss power, identify possible mechanisms of action, and recommend their best adoption. Full article
(This article belongs to the Special Issue Mechanisms of Hair Morphology)
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