Molecular Mechanisms, Emerging Biomarkers, Novel Therapies and Personalized Treatment in Celiac Disease (CD)
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: closed (20 September 2025) | Viewed by 512
Special Issue Editor
Interests: celiac disease; intestinal organoids; extracellular microvesicles in liquid biopsy; immune checkpoints
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Understanding the molecular mechanisms of CD, coupled with the development of new biomarkers and therapies, are contributting for more effective and personalized management of the disease. Advances in research continue to hold promise for improving the quality of life for individuals affected by celiac disease. Emerging biomarkers are being developed to improve the diagnosis and management of CD. These include deamidated gliadin peptides (DGPs), cytokine profiles, microRNAs, and markers of intestinal permeability. Microbial biomarkers and specific proteins found in blood and stool are also being explored for their potential to enhance diagnostic accuracy and monitor disease activity. In terms of novel therapies, there is ongoing research aimed at developing treatments that go beyond the traditional gluten-free diet (GFD). Some strategies include enzyme therapies to break down gluten, gluten-sequestering agents, inhibitors of TG2 to prevent the immune response, and therapies to modulate intestinal permeability and the gut microbiome. Additionally, nanoparticle-based delivery systems and genetic and cell-based therapies, such as gene editing and adoptive cell transfer, are being investigated for their potential to offer more personalized and effective treatment options. These advancements hold promise for improving the quality of life for individuals with CD by providing more precise diagnostic tools, better monitoring capabilities, and potentially curative treatments.
Thus, this Special Issue entitled ‘Molecular Mechanisms, Emerging Biomarkers, Novel Therapies and Personalized Treatment in Celiac Disease (CD) will explores recent advancements in understanding and managing CD.
Dr. María Isabel Torres
Guest Editor
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Keywords
- celiac disease
- gluten sensitivity
- immune response
- emerging biomarkers
- novel therapies
- microbiome modulation
- personalized treatment
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