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Cell Fate Decisions in Neural Development
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Cell Fate Decisions in Neural Development

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 11616

Special Issue Editor

Prof. Dr. Chaya Kalcheim

E-Mail Website
Guest Editor
Department of Medical Neurobiology, Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem, Israel
Interests: neural crest; neural tube; roof plate, somite; mesoderm; myogenesis; peripheral nervous system; cell migration; epithelial-to mesenchymal transition; neuronal specification; developmental neurobiology; developmental biology; avian embryo

Special Issue Information

Dear Colleagues,

The large diversity of cell types that set up the complexity of the central and peripheral branches of the nervous system originates from small groups of progenitors during embryonic development. The combinatorial expression of specific genes that define a given cell identity is controlled by interactions between signaling proteins, transcription factors, and epigenetic mechanisms.

Recent advances in methodologies addressing these diverse levels of regulation have opened new opportunities to answer classical questions of when and how progenitors adopt their final identity and turn into functionally distinct cells. It is the combination between this emerging, large-scale basis of knowledge, and established gain and loss of function approaches that will impact the field in the coming years.

The scope of this collection will cover cellular and molecular mechanisms leading to the acquisition of specific identities of progenitors issued from the neural tube and neural crest in vertebrate embryos. This includes interactions at the signaling, transcriptional, and translational levels of regulation. Studies addressing these questions that implement both in vivo models as well as in vitro approaches based on embryonic stem cells or induced pluripotent stem cells will be welcome.

Prof. Dr. Chaya Kalcheim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cell specification
  • cell lineage
  • cell-cell interactions
  • neural tube
  • neural crest
  • neuronal development
  • glial development
  • gene regulatory networks
  • gene editing
  • pattern formation
  • morphogenesis

Published Papers (3 papers)

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Research

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15 pages, 2756 KiB  
Article
Early Life Stage Folic Acid Deficiency Delays the Neurobehavioral Development and Cognitive Function of Rat Offspring by Hindering De Novo Telomere Synthesis
by Dezheng Zhou, Zhenshu Li, Yue Sun, Jing Yan, Guowei Huang and Wen Li
Int. J. Mol. Sci. 2022, 23(13), 6948; https://doi.org/10.3390/ijms23136948 - 22 Jun 2022
Cited by 4 | Viewed by 1836
Abstract
Early life stage folate status may influence neurodevelopment in offspring. The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from conception to 2 years) of life. This study aimed to evaluate the effect of [...] Read more.
Early life stage folate status may influence neurodevelopment in offspring. The developmental origin of health and disease highlights the importance of the period of the first 1000 days (from conception to 2 years) of life. This study aimed to evaluate the effect of early life stage folic acid deficiency on de novo telomere synthesis, neurobehavioral development, and the cognitive function of offspring rats. The rats were divided into three diet treatment groups: folate-deficient, folate-normal, and folate-supplemented. They were fed the corresponding diet from 5 weeks of age to the end of the lactation period. After weaning, the offspring rats were still fed with the corresponding diet for up to 100 days. Neurobehavioral tests, folic acid and homocysteine (Hcy) levels, relative telomere length in brain tissue, and uracil incorporation in telomere in offspring were measured at different time points. The results showed that folic acid deficiency decreased the level of folic acid, increased the level of Hcy of brain tissue in offspring, increased the wrong incorporation of uracil into telomeres, and hindered de novo telomere synthesis. However, folic acid supplementation increased the level of folic acid, reduced the level of Hcy of brain tissue in offspring, reduced the wrong incorporation of uracil into telomeres, and protected de novo telomere synthesis of offspring, which was beneficial to the development of early sensory-motor function, spatial learning, and memory in adolescence and adulthood. In conclusion, early life stage folic acid deficiency had long-term inhibiting effects on neurodevelopment and cognitive function in offspring. Full article
(This article belongs to the Special Issue Cell Fate Decisions in Neural Development)
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Review

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22 pages, 25585 KiB  
Review
Cell Fate Decisions in the Neural Crest, from Pigment Cell to Neural Development
by Jonathan H. P. Dawes and Robert N. Kelsh
Int. J. Mol. Sci. 2021, 22(24), 13531; https://doi.org/10.3390/ijms222413531 - 16 Dec 2021
Cited by 4 | Viewed by 3842
Abstract
The neural crest shows an astonishing multipotency, generating multiple neural derivatives, but also pigment cells, skeletogenic and other cell types. The question of how this process is controlled has been the subject of an ongoing debate for more than 35 years. Based upon [...] Read more.
The neural crest shows an astonishing multipotency, generating multiple neural derivatives, but also pigment cells, skeletogenic and other cell types. The question of how this process is controlled has been the subject of an ongoing debate for more than 35 years. Based upon new observations of zebrafish pigment cell development, we have recently proposed a novel, dynamic model that we believe goes some way to resolving the controversy. Here, we will firstly summarize the traditional models and the conflicts between them, before outlining our novel model. We will also examine our recent dynamic modelling studies, looking at how these reveal behaviors compatible with the biology proposed. We will then outline some of the implications of our model, looking at how it might modify our views of the processes of fate specification, differentiation, and commitment. Full article
(This article belongs to the Special Issue Cell Fate Decisions in Neural Development)
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20 pages, 1313 KiB  
Review
From Bipotent Neuromesodermal Progenitors to Neural-Mesodermal Interactions during Embryonic Development
by Nitza Kahane and Chaya Kalcheim
Int. J. Mol. Sci. 2021, 22(17), 9141; https://doi.org/10.3390/ijms22179141 - 24 Aug 2021
Cited by 4 | Viewed by 4924
Abstract
To ensure the formation of a properly patterned embryo, multiple processes must operate harmoniously at sequential phases of development. This is implemented by mutual interactions between cells and tissues that together regulate the segregation and specification of cells, their growth and morphogenesis. The [...] Read more.
To ensure the formation of a properly patterned embryo, multiple processes must operate harmoniously at sequential phases of development. This is implemented by mutual interactions between cells and tissues that together regulate the segregation and specification of cells, their growth and morphogenesis. The formation of the spinal cord and paraxial mesoderm derivatives exquisitely illustrate these processes. Following early gastrulation, while the vertebrate body elongates, a population of bipotent neuromesodermal progenitors resident in the posterior region of the embryo generate both neural and mesodermal lineages. At later stages, the somitic mesoderm regulates aspects of neural patterning and differentiation of both central and peripheral neural progenitors. Reciprocally, neural precursors influence the paraxial mesoderm to regulate somite-derived myogenesis and additional processes by distinct mechanisms. Central to this crosstalk is the activity of the axial notochord, which, via sonic hedgehog signaling, plays pivotal roles in neural, skeletal muscle and cartilage ontogeny. Here, we discuss the cellular and molecular basis underlying this complex developmental plan, with a focus on the logic of sonic hedgehog activities in the coordination of the neural-mesodermal axis. Full article
(This article belongs to the Special Issue Cell Fate Decisions in Neural Development)
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