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Novel Findings and Insights into Dietary Proteins and Bioactive Peptides in Gastrointestinal Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 3461

Special Issue Editors

Guest Editor
Instituto de Investigación en Ciencias de la Alimentación (CIAL), Consejo Superior de Investigaciones Científicas (CSIC). c/ Nicolás Cabrera 9, 28049 Madrid, Spain
Interests: bioactive peptides; food proteins; multifuncionality; digestion; bioavailability; inflammation-associated diseases; chemopreventive activity; peptidomics; antioxidant activity
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS-IP), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
Interests: bioactive peptides; food proteins; bioactivity; inflammatory bowel disease; biologics; intestinal mucosa; immunomodulation; digestion; gastrointestinal health; chronic diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The gastrointestinal tract represents the main interface for the interaction between dietary compounds and the organism. Precise control of gastrointestinal barrier is essential to maintain digestive functions and mucosal homeostasis, while alterations on these key regulatory mechanisms may lead to gastrointestinal disorders such as celiac disease, food allergies or inflammatory bowel diseases, among others. Hence, diet is one of the main environmental factors influencing gastrointestinal disorders as it modulates both the gut microbiota and the mucosal immune system. Among dietary compounds, food proteins and released peptides have acquired recent importance as nutraceutical and active components in functional foods, due to their regulatory functions and health-promoting benefits.

This Special Issue aims to cover a selection of recent research papers, reviews, as well as perspectives in the role of dietary proteins and bioactive peptides operating against gastrointestinal diseases. In particular, this Special Issue will highlight not only manuscripts from animal and human trials focused on evaluating the ability of bioactive peptides to endorse digestive health and prevent gastrointestinal disorders, but also in vitro or ex vivo studies aimed at elucidating the potential molecular mechanisms underlying these health-promoting effects.

Dr. Blanca Hernández-Ledesma
Dr. Samuel Fernández-Tomé
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • gastrointestinal disorders
  • food proteins
  • bioactive peptides
  • molecular mechanisms
  • antioxidative protection
  • anti-inflammatory activity
  • immunomodulatory effects
  • gut microbiota

Published Papers (1 paper)

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13 pages, 1652 KiB  
Peptides from the Intestinal Tract of Breast Milk-Fed Infants Have Antimicrobial and Bifidogenic Activity
by Robert L. Beverly, Prajna Woonnimani, Brian P. Scottoline, Jiraporn Lueangsakulthai and David C. Dallas
Int. J. Mol. Sci. 2021, 22(5), 2377; https://doi.org/10.3390/ijms22052377 - 27 Feb 2021
Cited by 14 | Viewed by 2552
For bioactive milk peptides to be relevant to infant health, they must be released by gastrointestinal proteolysis and resist further proteolysis until they reach their site of activity. The intestinal tract is the likeliest site for most bioactivities, but it is currently unknown [...] Read more.
For bioactive milk peptides to be relevant to infant health, they must be released by gastrointestinal proteolysis and resist further proteolysis until they reach their site of activity. The intestinal tract is the likeliest site for most bioactivities, but it is currently unknown whether bioactive milk peptides are present therein. The purpose of the present study was to identify antimicrobial and bifidogenic peptides in the infant intestinal tract. Milk peptides were extracted from infant intestinal samples, and the activities of the bulk peptide extracts were determined by measuring growth of Escherichia coli, Staphylococcus aureus, and Bifidobacterium longum spp. infantis after incubation with serial dilutions. The peptide profiles of active and inactive samples were determined by peptidomics analysis and compared to identify candidate peptides for bioactivity testing. We extracted peptides from 29 intestinal samples collected from 16 infants. Five samples had antimicrobial activity against S. aureus and six samples had bifidogenic activity for B. infantis. We narrowed down a list of 6645 milk peptides to 11 candidate peptides for synthesis, of which 6 fully inhibited E. coli and S. aureus growth at concentrations of 2500 and 3000 µg/mL. This study provides evidence for the potential bioactivity of milk peptides in the infant intestinal tract. Full article
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