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Special Issue "Involvement of Connexin Hemichannels in the Inflammatory Response of Chronic Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 May 2018).
Prof. Dr. Juan Carlos Saez Website E-Mail
1. Centro Interdisciplinario de Neurociencia de Valparaíso CINV, Instituto de Neurociencia, Facultad de Ciencias, Universidad de Valparaíso, Chile
2. Alameda 340, Laboratorio de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
Interests: Regulation and function of connexin- and pannexin-based channels
Prof. Colin Richard Green Website E-Mail
Department of Ophthalmology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
Interests: Gap junctions; Connexin channel modulation; Ocular disease; Diabetic retinopathy; Macular degeneration; Neurodegeneration; Wound healing
Connexin hemichannel opening has been implicated in a number of chronic inflammatory disease indications, including muscular dystrophy, amyotrophic lateral sclerosis, ongoing effects of CNS trauma, stroke or ischemia, glaucoma, diabetic retinopathy and macular degeneration, Alzheimer’s and Parkinson’s disease, epilepsy, chronic pain, and infectious diseases. Hemichannels play a key role in both injury spread and perpetuation of inflammatory processes. Whilst the search continues for more specific tools, judicious use of connexin channel blockers has provided remarkable evidence for new treatments to ameliorate tissue dysfunction in diverse chronic disease and even enable tissue regeneration.
This issue of the International Journal of Molecular Sciences will focus on the “Involvement of connexin hemichannels in the inflammatory response of chronic diseases”, bringing together the substantial evidence for common hemichannel-mediated tissue dysfunction associated with diverse chronic disease indications, supporting hemichannel regulation for clinical application.
Prof. Juan Carlos Saez
Prof. Colin Richard Green
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Connexin hemichannels
- Inflammasome pathway
- ATP release
- Intracellular free Ca2+
- Chronic inflammatory disease
- Therapeutics based on hemichannel blockers