Non-coding RNAs in Tumor Development and Angiogenesis

Dear Colleagues, 

Non-coding RNAs have been demonstrated to be important in cancer development, angiogenesis, biomarkers, and therapeutic resistance. micro-RNAs (miRNAs) are the first class of non-coding RNAs discovered in cancer development to have a therapeutic effect, and are the most extensively investigated ncRNAs in regulation of cancer initiation, development, angiogenesis, and therapeutic resistance. long-ncRNAs (lncRNAs) represent the largest class of non-coding RNAs, with more than 55,000 genes in the human genome,  and lncRNAs may regulate gene expression through their interactions with  proteins, miRNAs, DNA, and mRNAs.  Other ncRNAs may also play important roles in some forms of cancer development. NcRNAs may regulate multiple molecular and cellular processes, such as RNA stability, protein translation, post-transcriptional regulations, DNA methylation, chromatin remodeling, and signal transduction.

This Special Issue will focus on recent research to understand the networks and mechanisms of ncRNAs, especially miRNAs and LncRNAs, that are key regulators of cancer initiation, carcinogenesis, development, angiogenesis, cellular programs, and therapeutic resistance. Gaining improved understanding of the complex networks of ncRNAs and underlining molecular mechanisms will provide new opportunities to identify new biomarkers and to design new options for cancer treatments in the future.

Prof. Dr. Binghua Jiang
Dr. Ling-Zhi Liu
Guest Editors

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