Dear Colleagues,

Deregulation of cell cycle has long been regarded as a key feature of oncogenesis, and is critical for sustained proliferation and uncontrolled cell division in tumors. Inhibitors of cell cycle checkpoints have been investigated as cancer therapy, but adverse toxicities have impeded further development. Recently, the breakthrough of cyclin-dependent kinase inhibitors in breast cancer therapy has rekindled the interest in the field. Unravelling the molecular underpinnings of cell cycle regulators, such as the crosstalk with oncogenes and tumor suppressors, may expose mechanisms for cancer progression. Moreover, the advances in single-cell technologies and multi-omics technologies have yielded an unprecedented platform for the understanding of cell cycle biology.

This Special Issue, “Emerging Molecular Mechanisms of Cell Cycle Regulation: Opportunities for Cancer Intervention?” aims to cover emerging evidence of cell cycle perturbations in cancer cells, and to discuss potential therapeutic strategies that cover cancer research. Original research articles and review articles on aspects relevant to cell cycle regulation, including but not limited to cancer cell biology, drug discovery/target validation, drug combinations, and genomics/genetics, are welcome for submission to this Special Issue.

Dr. Li Ren Kong
Dr. Andrea L. Wong
Guest Editors

Manuscript Submission Information

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• cell cycle regulators
• molecular targets
• prognosis biomarkers
• cancer cell susceptibility
• synthetic lethality
• tumour heterogeneity
• clinical drug development