Special Issue "Capsaicin and TRPV1 in the Study of Pain and Organ Pathologies"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2019).
Capsaicin, a selective nociceptor excitant and a unique neurotoxic agent affecting C-fiber nociceptive primary sensory neurons, has become an indispensable tool in pain research and in studies concerned with the role of sensory nerves in various organ functions. Capsaicin/TRPV1 receptor-expressing chemosensitive afferent nerves are widely distributed in the body and play important roles in various organ functions. This Special Issue focuses on the mechanism(s) of action of vanilloid compounds and the involvement of sensory nerves expressing capsaicin/TRPV1 receptor (and other TRP receptors, such as TRPA1 co-expressed with TRPV1) in the function of the pain system and in (patho)physiological processes affecting different organ systems.
Possible topics may include: 1) the cellular mechanism(s) of the sensory excitatory, sensitizing, desensitizing, and neurotoxic actions of capsaicin, 2) the use of capsaicin as a specific research tool to investigate the involvement of capsaicin/TRPV1/TRPA1 receptor-expressing chemosensitive sensory nerves in pathophysiological processes such as pain, inflammation, nerve and tissue injury, metabolism, tumor development, etc., and, 3) the possible therapeutic perspectives of vanilloid agonists and antagonists in the management of pain and inflammation.
Prof. Gábor Jancsó
Manuscript Submission Information
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- Primary sensory neurons
- Peripheral nerve injury
- Sensory neuropeptides
- Organ pathology