Special Issue "Analysing Bacterial Infection, Microbiome Characterics and Small Molecules in Diagnostics: Emerging Options"
Deadline for manuscript submissions: 31 October 2020.
Interests: diagnostic assays; new biomarker approaches; small molecule quantification; endogenous metabolites
Interests: Microbiology; Moleculer microbiology; Infection diseases Loop Mediated isothermal amplification (LAMP) method; RT-PCR; Point of care (POC); Labonadisc; Aptasensor
The conserved nature of host responses offers new approaches for diagnostic development in infectious diseases. Routine diagnostic methods are very useful but do not provide enough sensitivity and specificity. For many decades, a diverse range of analytical targets such as metabolites, nucleic acids, proteins are established as biomarkers now also including parts of the microbiome and one objective of this special issue will be evaluation of the role of emerging host and microbial biomarkers in diagnosis of infectious diseases.
In fact, the development of universal and reliable methods to detect biomarkers for diagnostics and prognostics and the search for highly specific and sensitive biomarkers for infectious diseases and beyond have posed the biggest challenges and options now include analysis of the structure and functionality of complex microbial communities in the human microbiome.
Aptamers for instance are now providing opportunities for quantitative diagnostic assays although translation into practice remains challenging in many cases. Aptamers are highly stable, short nucleic acid sequences capable of binding to the target with high affinity and specificity; small molecules that are problematic for toxins, proteins, cells, and even antibodies can be targeted by aptamers. The technology (applied in chip- or horizontal flow tests), the target analyte can be quickly detected of target molecules in quantitative and multiplex formats, also on-site in miniaturized portable systems requiring less reagents, energy, and no special infrastructure and laborious/long sample preparation. These systems provide a high level of integration and automation. Emerging options for quantification of large and in small molecules by additional novel approaches will also be covered by this special issue.
Prof. Dr. Hans-Peter Deigner
Dr. Esra Aǧel
Dr. Markus Egert
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Assay systems development
- Point-of-care testing
- Metabolomic and proteomic approaches
- Host response diagnostics
- Infectious diseases diagnostics
- Small molecule biomarkers
- Gene expression profiling