Next Article in Journal
Description of AtCAX4 in Response to Abiotic Stress in Arabidopsis
Previous Article in Journal
Survival Pathways Are Differently Affected by Microgravity in Normal and Cancerous Breast Cells
Previous Article in Special Issue
Emerging Options for the Diagnosis of Bacterial Infections and the Characterization of Antimicrobial Resistance
Review

Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria

1
Center for Precision Medicine, Hochschule Furtwangen University, Jakob-Kienzle-Str. 17, 78054 Villingen-Schwenningen, Germany
2
Department of Biosciences, COMSATS University Islamabad, Park Road, Tarlai Kalan, Islamabad 45550, Pakistan
3
Mechano(bio)chemistry, Max Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, Golm, 14476 Potsdam, Germany
4
EXIM Department, Fraunhofer Institute IZI, Leipzig, Schillingallee 68, 18057 Rostock, Germany
5
Faculty of Science, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2021, 22(2), 859; https://doi.org/10.3390/ijms22020859
Received: 22 December 2020 / Revised: 11 January 2021 / Accepted: 13 January 2021 / Published: 16 January 2021
Life-threatening bacterial infections have been managed by antibiotics for years and have significantly improved the wellbeing and lifetime of humans. However, bacteria have always been one step ahead by inactivating the antimicrobial agent chemically or by producing certain enzymes. The alarming universal occurrence of multidrug-resistant (MDR) bacteria has compelled researchers to find alternative treatments for MDR infections. This is a menace where conventional chemotherapies are no longer promising, but several novel approaches could help. Our current review article discusses the novel approaches that can combat MDR bacteria: starting off with potential nanoparticles (NPs) that efficiently interact with microorganisms causing fatal changes in the morphology and structure of these cells; nanophotothermal therapy using inorganic NPs like AuNPs to destroy pathogenic bacterial cells; bacteriophage therapy against which bacteria develop less resistance; combination drugs that act on dissimilar targets in distinctive pathways; probiotics therapy by the secretion of antibacterial chemicals; blockage of quorum sensing signals stopping bacterial colonization, and vaccination against resistant bacterial strains along with virulence factors. All these techniques show us a promising future in the fight against MDR bacteria, which remains the greatest challenge in public health care. View Full-Text
Keywords: multidrug resistance; nanoantibiotics; nanoparticles; combination therapy; bacteriophages multidrug resistance; nanoantibiotics; nanoparticles; combination therapy; bacteriophages
Show Figures

Figure 1

MDPI and ACS Style

Khan, A.A.; Manzoor, K.N.; Sultan, A.; Saeed, M.; Rafique, M.; Noushad, S.; Talib, A.; Rentschler, S.; Deigner, H.-P. Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria. Int. J. Mol. Sci. 2021, 22, 859. https://doi.org/10.3390/ijms22020859

AMA Style

Khan AA, Manzoor KN, Sultan A, Saeed M, Rafique M, Noushad S, Talib A, Rentschler S, Deigner H-P. Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria. International Journal of Molecular Sciences. 2021; 22(2):859. https://doi.org/10.3390/ijms22020859

Chicago/Turabian Style

Khan, Abid A., Khanzadi N. Manzoor, Aamir Sultan, Maria Saeed, Mahrukh Rafique, Sameen Noushad, Ayesha Talib, Simone Rentschler, and Hans-Peter Deigner. 2021. "Pulling the Brakes on Fast and Furious Multiple Drug-Resistant (MDR) Bacteria" International Journal of Molecular Sciences 22, no. 2: 859. https://doi.org/10.3390/ijms22020859

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop