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Special Issue "Molecular Research on Arboviruses Infection"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 April 2020.
Emerging and existing arboviruses represent a constant threat in all regions of the world. Understanding the molecular mechanisms of pathogenesis and protective immunity is an important endeavour for designing new therapeutic interventions. The molecular pathogenesis of arbovirus infections describes our current understanding of the pathogenesis of selected arboviruses, such as dengue, Zika, West Nile, Rift Valley fever, chikungunya, and many others. Molecular pathogenesis may focus on, but is not restricted to, for instance tropism, host–pathogen interactions at a cellular and molecular level, study of virulence factors, mico-evolution, host resistance to pathogens, and factors driving the emergence of new viruses. Deciphering the specific aberrant cell signalling pathways in disease caused by arboviruses is an important piece in the molecular biology puzzle underlying these diseases. Understanding the ubiquitous pathways implicated in the disease, providing numerous potential therapeutic targets, may also be crucial for researchers in order to move forward. Consider, for instance, dengue, which consists of four serotypes. Although primary infection confers durable, if not life-long protection against re-infection by a homologous dengue virus serotype, secondary infection by a heterologous serotype is considered the most important risk factor for severe disease. However, the molecular mechanisms of, for instance, antibody-dependent enhancement, antibody glycosylation, original antigenic sin, mitochondrial dysfunction, pyroptosis, endothelium cell permeability, and so on, which have been associated with severe diseases remaining poorly understood. This Special Issue aims to bring this knowledge together and to identify the gaps in our understanding of the molecular mechanisms of evolution and pathogenesis.
Dr. Byron Martina
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Arboviruses Infection
- Virulence Factors
- Molecular Pathogenesis
- Cell Death
- Aberrant Cell Signaling Pathways
- Therapeutic Targets