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Article

Inhibition of Orbivirus Replication by Aurintricarboxylic Acid

Animal Health Research Centre (CISA), National Institute for Agriculture and Food Research and Technology (INIA), Valdeolmos, 28130 Madrid, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(19), 7294; https://doi.org/10.3390/ijms21197294
Received: 28 August 2020 / Revised: 28 September 2020 / Accepted: 30 September 2020 / Published: 2 October 2020
(This article belongs to the Special Issue Molecular Research on Arboviruses Infection)
Bluetongue virus (BTV) and African horse sickness virus (AHSV) are vector-borne viruses belonging to the Orbivirus genus, which are transmitted between hosts primarily by biting midges of the genus Culicoides. With recent BTV and AHSV outbreaks causing epidemics and important economy losses, there is a pressing need for efficacious drugs to treat and control the spread of these infections. The polyanionic aromatic compound aurintricarboxylic acid (ATA) has been shown to have a broad-spectrum antiviral activity. Here, we evaluated ATA as a potential antiviral compound against Orbivirus infections in both mammalian and insect cells. Notably, ATA was able to prevent the replication of BTV and AHSV in both cell types in a time- and concentration-dependent manner. In addition, we evaluated the effect of ATA in vivo using a mouse model of infection. ATA did not protect mice against a lethal challenge with BTV or AHSV, most probably due to the in vivo effect of ATA on immune system regulation. Overall, these results demonstrate that ATA has inhibitory activity against Orbivirus replication in vitro, but further in vivo analysis will be required before considering it as a potential therapy for future clinical evaluation. View Full-Text
Keywords: Orbivirus; Arbovirus; Bluetongue virus; African horse sickness virus; aurintricarboxylic acid; antiviral Orbivirus; Arbovirus; Bluetongue virus; African horse sickness virus; aurintricarboxylic acid; antiviral
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MDPI and ACS Style

Alonso, C.; Utrilla-Trigo, S.; Calvo-Pinilla, E.; Jiménez-Cabello, L.; Ortego, J.; Nogales, A. Inhibition of Orbivirus Replication by Aurintricarboxylic Acid. Int. J. Mol. Sci. 2020, 21, 7294. https://doi.org/10.3390/ijms21197294

AMA Style

Alonso C, Utrilla-Trigo S, Calvo-Pinilla E, Jiménez-Cabello L, Ortego J, Nogales A. Inhibition of Orbivirus Replication by Aurintricarboxylic Acid. International Journal of Molecular Sciences. 2020; 21(19):7294. https://doi.org/10.3390/ijms21197294

Chicago/Turabian Style

Alonso, Celia, Sergio Utrilla-Trigo, Eva Calvo-Pinilla, Luis Jiménez-Cabello, Javier Ortego, and Aitor Nogales. 2020. "Inhibition of Orbivirus Replication by Aurintricarboxylic Acid" International Journal of Molecular Sciences 21, no. 19: 7294. https://doi.org/10.3390/ijms21197294

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