Cholesterol and Lipoprotein Metabolism 2.0
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (25 December 2023) | Viewed by 14757
Special Issue Editor
Interests: lipoproteins; atherosclerosis; coronary heart disease; familial hypercholesterolemia; low-density lipoprotein (LDL) receptor; heart failure; gene therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cholesterol is an essential structural component of all animal cell membranes. It was isolated from gallstones by the French doctor and chemist François Poulletier de la Salle in 1758. Cholesterol is a determinant of both cell membrane structural integrity and fluidity, and is critical for cell and organ function. The German chemist and Nobel Prize winner A. Windaus reported in 1910 that atherosclerotic plaques from human aortas contained over 20-fold higher concentrations of cholesterol than normal aortas did. Since then, several lines of evidence have established a causal connection between blood cholesterol, atherosclerosis, and coronary heart disease.
All proatherogenic lipoproteins contain apolipoprotein B. The retention of proatherogenic lipoproteins within the vessel wall is the obligatory initiating event of atherogenesis. The retained lipoproteins trigger an inflammatory response that is accompanied by lesion progression and the formation of advanced atherosclerotic plaques. Increased remnant lipoproteins are considered to constitute an important determinant of residual cardiovascular risk in patients with adequately lowered levels of low-density lipoprotein cholesterol.
The scientific fields of cholesterol homeostasis, lipoprotein metabolism, atherosclerosis, and ischemic heart disease remain inexhaustible sources of challenging questions and discovery. This Special Issue will cover recent advances in these fields.
Prof. Dr. Bart De Geest
Guest Editor
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Keywords
- cholesterol
- lipoproteins
- atherosclerosis
- coronary heart disease
- remnant lipoproteins
- low-density lipoproteins
- apolipoprotein B
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