Diagnostic and Therapeutic Advances in the Management of Sepsis and Septic Shock—2nd Edition

Dear Colleagues,

We are delighted to present this Special Issue of the International Journal of Molecular Sciences: “Diagnostic and Therapeutic Advances in the Management of Sepsis and Septic Shock—2nd Edition”, as Volume 1 of the Special Issue was successful.

The conceptual framework for the diagnosis of sepsis, septic shock and endotoxic shock has multiple steps, including an initial evaluation of the etiology and clinical features, assessment of the primary hemodynamic manifestations, and consideration of the alterations in cellular biology and the degree of local tissue injury. The prompt diagnosis of septic shock begins with obtainment of the patient’s medical history and the performance of a physical examination to identify the signs and symptoms of infection; the patient may also require focused ultrasonography to recognize more complex physiologic manifestations of shock. The identification of biomarkers is particularly important to understand molecular mechanisms and diagnose sepsis, enabling early intervention, which can reduce the risk of death. In fact, a sample treatment algorithm for septic shock typically proceeds through the rescue, optimization, stabilization, and de-escalation of care. Many adjunctive treatments in septic shock target perturbations in the innate immune response and coagulation cascade. An example of this is extracorporeal blood purification therapy, which has been proposed to improve outcomes in patients with sepsis. Therefore, IJMS is proud to offer this platform to promote and highlight valuable research on “Diagnostic and Therapeutic Advances in the Management of Sepsis and Septic Shock—2nd Edition”.

Dr. Silvia De Rosa
Guest Editor

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• antibiotics
• biomarkers
• blood purification in sepsis
• endotoxic shock
• imaging
• infectious disease
• resuscitation
• biomarkers
• septic shock
• sepsis-associated AKI