Dietary Nitrate and Metabolic Health

Dear Colleagues,

Nitric oxide (NO) is endogenously generated from L-arginine and oxygen by NO synthases. In addition, inorganic nitrate from dietary sources generates NO and nitrosating agents, such as the S-nitroso compound, in the acidic stomach, thus providing local and systemic NO bioactivities. Recent evidence suggests that local and systemic NO bioavailability is associated with health maintenance through the nitrate–nitrite–NO pathway, and it is affected by many habitual and physiological factors, including dietary habits, oral commensal bacteria, gastric acidity, intestinal bacterial flora, and thiol-containing food and drugs. Therefore, it is important to discuss the association between diet, including dietary nitrate, and metabolic health from biological and physiological standpoints. Although dietary nitrate provides beneficial effects, it is a source of carcinogenic N-nitroso compounds under certain physiological conditions. Thus, this Special Issue also welcomes studies dealing with controversial findings. I look forward to fruitful discussions regarding dietary nitrate and metabolic health in this Special Issue. I welcome submissions of both original articles and reviews that will offer the readers of IJMS new findings and comprehensive explanations on dietary nitrate and metabolic health. These are necessary for the development of novel research approaches, particularly those related to health maintenance strategies.

Prof. Dr. Jun Kobayashi
Guest Editor

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