Molecular and Cellular Mechanisms in Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 7
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue will explore how metabolic pathways regulate vascular cell function and dysfunction, with a particular focus on cross-talk between endothelial, smooth muscle, perivascular, and immune cells. Metabolic remodelling in the vascular wall is increasingly recognised as a driver of major diseases, including atherosclerosis, diabetes-associated vascular complications, hypertension, cerebrovascular disease, and heart failure, as well as systemic conditions such as chronic kidney disease, obesity, and ageing.
We welcome original research and comprehensive reviews that investigate the following:
- Nutrient sensing and metabolic adaptation in endothelial and smooth muscle cells across vascular beds;
- Metabolic cross-talk between vascular and immune cells inatherosclerosis and vascular inflammation;
- The interplay betweenmechanical forces (shear stress, arterial stiffness) and vascular metabolism;
- Nutrient and metabolite flux, including the role of themicrobiome and diet-derived metabolites, in vascular health and disease;
- Translational approaches, such asmetabolomics, fluxomics, imaging, and biomarker discovery, as well as novel metabolic therapies for vascular protection.
By bringing together mechanistic and translational studies, this issue will provide new insights into how metabolic signalling contributes to vascular dysfunction across cardiometabolic and age-related diseases, and highlight potential therapeutic strategies targeting vascular metabolism.
Dr. Paul Meakin
Guest Editor
Manuscript Submission Information
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Keywords
- vascular cell function
- atherosclerosis
- diabetes-associated vascular complications
- hypertension
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