Synthesis and Biological Evaluation of Pyrazole Derivatives

Dear Colleagues,

Blockbuster drugs (e.g., Acomplia®, Celebrex®), as well as a number of promising compounds endowed with various biological activities, are characterized by the pyrazole substructure. Pyrazole-containing molecules display a broad range of biological activities, including anti-inflammatory, anticancer, antiviral, antibacterial, antifungal, and selective enzyme inhibition properties.

The pharmacological properties of this heterocycle are related to its particular chemical behavior. In fact, the two pyrazole nitrogen atoms (namely, “pyrrole-like” and “pyridine-like” nitrogen) are characterized by different electronic properties, allowing reactivity with both acids and basis. Furthermore, pyrazole is endowed with prototrophic tautomerism that can be relevant in interactions with several pharmacological targets.

This Special Issue highlights the interest of the scientific community in this heterocycle and will focus on medicinal chemistry studies oriented towards the design, synthesis, and biological characterization of novel, differently decorated pyrazole derivatives. The results reported in the Special Issue will further support medicinal chemists interested in exploiting the pharmaceutical potential of pyrazole-containing derivatives.

Dr. Andrea Spallarossa
Dr. Chiara Brullo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• pyrazole compounds
• medicinal chemistry
• drug design
• drug synthesis
• biological properties
• drug discovery
• structure–activity relationships
• organic synthesis