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Advanced Research of Gut Microbiota and Toxins

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 1079

Special Issue Editor


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Guest Editor
1. Department of Biomedical Laboratory Science, College of Software and Digital Healthcare Convergence, Yonsei University MIRAE Campus, Wonju 26493, Republic of Korea
2. Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute, College of Medicine, Gachon University, 155 Gaetbeol-ro, Yeonsu-gu, Inchon 21999, Republic of Korea
Interests: gut inflammation; colitis; colitis-associated cancer; gut microbiota; bacterial infection; inflammatory bowel diseases; colorectal cancer; gut–organ axis
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Special Issue Information

Dear Colleagues,

The gut microbiota is a master regulator of human health. It is increasingly recognized as a pivotal regulator of human health and disease. From commensal to pathogenic bacteria, the composition and function of the gut microbiota profoundly influences host physiology and inflammation.

We welcome papers that not only study molecular mechanisms but also cell and animal phenotypic studies and study models and protocols to understand diseases associated with the gut microbiota. Furthermore, we are interested in the bacterial toxin-mediated mechanism of inflammation or inflammation-associated tumor models using various cell lines or mouse models.  We also invite submissions exploring the intricate relationship between the gut microbiota and inflammatory diseases. Topics of interest include:
  • Mechanisms of disease pathogenesis, specifically studies elucidating the molecular mechanisms underlying the gut microbiota’s contribution to colitis or intestinal inflammation-mediated diseases;
  • Therapeutic targets, specifically studies identifying novel therapeutic targets and strategies based on modulating the gut microbiota;
  • Development of a method to induce the mouse model, specifically  methodological papers on the techniques and protocols for constructing mouse inflammation and tumor models using clinically important microorganisms.
  • Disease-associated phenotypes, specifically through studies characterizing the unique microbial signatures associated with different diseases, including colitis or colitis-associated cancer.

Dr. Soonjae Hwang
Guest Editor

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Keywords

  • gut microbe
  • toxins
  • gut commensal
  • infectious disease
  • gut microbiota
  • gut microbiome
  • inflammatory diseases
  • colon cancer

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Published Papers (1 paper)

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Review

23 pages, 4146 KiB  
Review
Human Gut Microbiome: A Connecting Organ Between Nutrition, Metabolism, and Health
by Sandra Valencia, Martha Zuluaga, María Cristina Florian Pérez, Kevin Fernando Montoya-Quintero, Mariana S. Candamil-Cortés and Sebastian Robledo
Int. J. Mol. Sci. 2025, 26(9), 4112; https://doi.org/10.3390/ijms26094112 - 26 Apr 2025
Viewed by 872
Abstract
The gut microbiome plays a vital role in human health, functioning as a metabolic organ that influences nutrient absorption and overall well-being. With growing evidence that dietary interventions can modulate the microbiome and improve health, this review examines whether healthcare systems should prioritize [...] Read more.
The gut microbiome plays a vital role in human health, functioning as a metabolic organ that influences nutrient absorption and overall well-being. With growing evidence that dietary interventions can modulate the microbiome and improve health, this review examines whether healthcare systems should prioritize personalized microbiome-targeted therapies, such as probiotics, prebiotics, and microbiota transplants, over traditional pharmaceutical treatments for chronic diseases like obesity, diabetes, cardiovascular risk, and inflammatory conditions. A systematic review using Web of Science and Scopus databases was conducted, followed by a scientometric analysis. Key metabolic pathways, such as dietary fiber fermentation and short-chain fatty acid production, were explored, focusing on their impact on lipid and glucose metabolism. The interactions between microbial metabolites and the immune system were also investigated. Dietary interventions, including increased fiber and probiotic intake, show potential for addressing dysbiosis linked to conditions, such as type 2 diabetes, obesity, and autoimmune diseases. The review emphasizes the need to incorporate microbiome modulation strategies into clinical practice and research, calling for a multidisciplinary approach that integrates nutrition, microbiology, and biochemistry to better understand the gut microbiome’s complex role in health. Full article
(This article belongs to the Special Issue Advanced Research of Gut Microbiota and Toxins)
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