Radiobiology and Radiotherapy in Tumour
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 10 June 2024 | Viewed by 2869
Special Issue Editors
2. UniSA Allied Health and Human Performance, University of South Australia, Adelaide 5000, Australia
Interests: modelling of tumour growth and development; risk of second cancer; personalised radiotherapy; treatment resistance; radiobiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 2023, the research community is still trying to elucidate the complex mechanisms behind one of the main causes of treatment failure in radiation oncology—tumour repopulation during treatment. There have been 35 years since the landmark publication by R. Withers et al. on The hazard of accelerated tumor clonogen repopulation during radiotherapy (Acta Oncol. 27:131), a paper that discusses accelerated tumour regrowth in head and neck carcinomas and presents quantitative parameters for the clonogen-doubling rate and the onset of tumour repopulation during radiotherapy.
Today, there is evidence towards the existence of cancer stem cells that are responsible for tumour repopulation, dissemination, and distant metastases in most solid cancers. Formerly known as clonogenic cells, cancer stem cells are closely investigated by the research community to understand their role in various biological processes that lead to tumour aggressiveness and, eventually, treatment failure. Repopulation during treatment is not limited to radiotherapy, as there is clinical proof for activating repopulation mechanisms through other conventional treatment techniques as well.
Whether in vivo, in vitro or in silico, all research aspects that explain diverse cellular properties responsible for tumour repopulation during treatment are welcome additions to current knowledge and to this Special Issue. We also encourage research on the cellular and molecular mechanisms involved in the response of tumour and normal tissues to ionizing radiation, as well as new insights into the molecular biological effects of radiation on tumour metabolism, cancer stem cells, the tumour microenvironment and novel environments.
Prof. Dr. Loredana Marcu
Prof. Dr. Eva Bezak
Guest Editors
Manuscript Submission Information
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Keywords
- accelerated repopulation
- radiotherapy
- chemotherapy
- cancer stem cells
- tumor microenvironment
- cancer therapy
- tumor metabolism
- molecular mechanisms
