Multi-Omics Approaches for Health and Disease

Dear Colleagues,

Gut, skin and respiratory environments consist of interaction networks of multiple organisms. Individual organisms and biofilms contribute to these networks through various proteomic activities and metabolic exchanges.

The recent trends have highlighted that one omic platform is no longer sufficient in systems biology. While genomic/transcriptomic studies highlight the expressions of specific genes, these expressions do not completely address the interaction omics. Similarly, numerous metabolism-based analytical chemistry studies have indicated that similar types of metabolites are involved in multiple biochemical reactions, decreasing the utilization of individual metabolites as effective biomarkers. Instead, it has been increasingly observed that a biomarker panel, a mix of certain metabolites and proteins, combined with specific genomic aspects (e.g., certain microbial species or individual gene/gene sets), could be a more reliable biomarker.

Bioinformatic toolboxes analyse integrated proteome/metabolome and genome/metabolome datasets and biochemical interactions. Newer AI-ML-based platforms are employed to analyse these large datasets for biomarker discovery, and host–parasite–microbiome interactions, among others. These applications are applied to address the mechanisms of multi-organ axes, antimicrobial resistance (AMR), and biological passports.

This Special Issue “Multi-Omics Approaches for Health and Disease” aims to explore the applications of integrated multiomics in various diseases, disorders, infections and nutritional aspects to develop the field of precision medicine in clinical and veterinary health. We welcome original scientific research articles, comprehensive reviews, communications, case reports, letters, commentaries and editorials that contribute to this field.

Dr. Avinash V. Karpe
Guest Editor

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