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Redox Modulation: Biological and Therapeutical Implication
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Redox Modulation: Biological and Therapeutical Implication

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 6771

Special Issue Editors

Prof. Dr. Claudio Santi

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Guest Editor
Group of Catalysis and Organic Grenn Chemistry, Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, PG, Italy
Interests: selenium; catalysis; green chemistry; flow chemistry; synthetic methodologies; redox; complexity
Special Issues, Collections and Topics in MDPI journals
Dr. Luca Sancineto

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Guest Editor
Department of Heteroorganic Chemistry, Center of Molecular and Macromolecular Studie of the Polish Academy of Sciences, Lódz, Poland
Interests: Medicinal Chemistry; Chemistry of Organoselenium Compounds; Redox Catalysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Redox reactions are involved in several biochemical pathways, playing a key role in both physiological and pathological events. Redox equilibria in living systems, as well as the modulation of the redox signaling, are even more frequently studied as targets for a novel class of therapeutic compounds, and to explain the mechanism of several pathologies. All contributions focused in the field will be welcome in this Special Issue, with particular interest on the development of new redox modulators, and drugs acting via redox mechanisms. We will also appreciate new insights into the molecular mechanisms of redox enzymes and proteins, and their mimetics.

Prof. Dr. Claudio Santi
Dr. Luca Sancineto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

22 pages, 5095 KiB  
Article
Complexity of NAC Action as an Antidiabetic Agent: Opposing Effects of Oxidative and Reductive Stress on Insulin Secretion and Insulin Signaling
by Lital Argaev-Frenkel and Tovit Rosenzweig
Int. J. Mol. Sci. 2022, 23(6), 2965; https://doi.org/10.3390/ijms23062965 - 09 Mar 2022
Cited by 3 | Viewed by 2299
Abstract
Dysregulated redox balance is involved in the pathogenesis of type 2 diabetes. While the benefit of antioxidants in neutralizing oxidative stress is well characterized, the potential harm of antioxidant-induced reductive stress is unclear. The aim of this study was to investigate the dose-dependent [...] Read more.
Dysregulated redox balance is involved in the pathogenesis of type 2 diabetes. While the benefit of antioxidants in neutralizing oxidative stress is well characterized, the potential harm of antioxidant-induced reductive stress is unclear. The aim of this study was to investigate the dose-dependent effects of the antioxidant N-acetylcysteine (NAC) on various tissues involved in the regulation of blood glucose and the mechanisms underlying its functions. H2O2 was used as an oxidizing agent in order to compare the outcomes of oxidative and reductive stress on cellular function. Cellular death in pancreatic islets and diminished insulin secretion were facilitated by H2O2-induced oxidative stress but not by NAC. On the other hand, myotubes and adipocytes were negatively affected by NAC-induced reductive stress, as demonstrated by the impaired transmission of insulin signaling and glucose transport, as opposed to H2O2-stimulatory action. This was accompanied by redox balance alteration and thiol modifications of proteins. The NAC-induced deterioration of insulin signaling was also observed in healthy mice, while both insulin secretion and insulin signaling were improved in diabetic mice. This study establishes the tissue-specific effects of NAC and the importance of the delicate maintenance of redox balance, emphasizing the challenge of implementing antioxidant therapy in the clinic. Full article
(This article belongs to the Special Issue Redox Modulation: Biological and Therapeutical Implication)
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13 pages, 4614 KiB  
Communication
PhSeZnCl in the Synthesis of Steroidal β-Hydroxy-Phenylselenides Having Antibacterial Activity
by Izabella Jastrzebska, Stefano Mellea, Valerio Salerno, Pawel Adam Grzes, Leszek Siergiejczyk, Katarzyna Niemirowicz-Laskowska, Robert Bucki, Bonifacio Monti and Claudio Santi
Int. J. Mol. Sci. 2019, 20(9), 2121; https://doi.org/10.3390/ijms20092121 - 29 Apr 2019
Cited by 13 | Viewed by 3244
Abstract
We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, [...] Read more.
We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation. Full article
(This article belongs to the Special Issue Redox Modulation: Biological and Therapeutical Implication)
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