Special Issue "Chalcogens in Catalysis: Synthesis and Biology"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalytic Materials".

Deadline for manuscript submissions: 30 November 2019

Special Issue Editors

Guest Editor
Prof. Claudio Santi

Professor of Organic Chemistry at Department of Pharmaceutical Sciences, University of Perugia, Via del Liceo 1, Perugia 06100, Italy
Website | E-Mail
Interests: organic synthesis; selenium chemistry; catalysis; bioorganic redox; green chemistry
Guest Editor
Prof. Dr. Eder Joao Lenardao

Center of Chemical, Pharmaceutical and Food Sciences, Federal University of Pelotas, Campus do Capão do Leão – 96010-900, Pelotas-RS, Brazil
Website | E-Mail
Phone: +55-53-3275-7356
Interests: organic synthesis; green chemistry; organoselenium; organochalcogen; ionic liquids; sonochemistry

Special Issue Information

Dear Colleagues,

Chalcogen-based reagents bear a high potential for the improvement of known reactions, not only from an environmental and pharmaceutical point of view, but also as interesting reagents for the development of completely new synthetic transformations and as potential ligands in catalytic reactions. Probably the most interesting aspect, emerged in recent years, involves the possibility to perform some functional group conversions using catalytic amounts of the chalcogen reagents or using chalcogen containing compounds as chiral ligands in metal catalyzed reactions. The developments of all these catalytic processes represent the most important results which have been reported recently in this field and their conceptual and synthetic relevance considerably increases the use of some derivatives as Green Catalysts. Considering that in nature, the main biological function of selenium and sulphur is associated with the incorporation of selenium in the form of selenocysteine (Sec) into certain proteins having redox motifs that use thiols as cofactors, different chalcogen containing compounds can be investigated as bio-inspired catalysts or biomimetic agent exploiting their biological activity through a catalytic mechanism.

This Special Issue focuses on recent advances in the field and original papers, as well as commentary, prospective, and review articles are welcome.

Prof. Dr. Claudio Santi
Prof. Dr. Eder Joao Lenardao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

View options order results:
result details:
Displaying articles 1-3
Export citation of selected articles as:

Research

Open AccessArticle
Towards New Catalytic Antioxidants: A Simple and Mild Synthesis of Selenenylsulfides
Catalysts 2019, 9(4), 333; https://doi.org/10.3390/catal9040333
Received: 14 March 2019 / Revised: 28 March 2019 / Accepted: 28 March 2019 / Published: 4 April 2019
PDF Full-text (813 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A new methodology for the synthesis of small molecules containing the S-Se bond is reported. Aryl- and alkyl-selenols react smoothly with N-thiophthalimides to afford the corresponding selenenylsulfides through a clean SN2 path occurring at the sulfur atom. The reaction proceeds [...] Read more.
A new methodology for the synthesis of small molecules containing the S-Se bond is reported. Aryl- and alkyl-selenols react smoothly with N-thiophthalimides to afford the corresponding selenenylsulfides through a clean SN2 path occurring at the sulfur atom. The reaction proceeds under very mild conditions in DMF in absence of catalysts for most of the substrates. The scope of the reaction was found to be broad, allowing a wide series of selenols and N-thiophtalimides to be efficiently employed in this procedure. Owing to the instability of the S-Se bond, selenenylsulfides exhibited a remarkable tendency to disproportionate to the corresponding symmetric diselenides and disulfides. Preliminary evaluation of the catalytic antioxidant properties of novel selenenylsulfides showed their behaviour as GPx mimics. Full article
(This article belongs to the Special Issue Chalcogens in Catalysis: Synthesis and Biology)
Figures

Graphical abstract

Open AccessArticle
Rational Design of Chiral Selenium-π-Acid Catalysts
Catalysts 2019, 9(2), 153; https://doi.org/10.3390/catal9020153
Received: 16 January 2019 / Revised: 25 January 2019 / Accepted: 28 January 2019 / Published: 3 February 2019
PDF Full-text (2711 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
A series of unprecedented chiral selenium-π-acid catalysts for the asymmetric, oxidative functionalization of alkenes has been developed. In total, eleven different chiral dihydrodiselenocine and (di-)alkoxyphenyl (di)selenide motifs have been synthesized in a concise, modal, and straightforward fashion. Commercially available, non-racemic alcohols have been [...] Read more.
A series of unprecedented chiral selenium-π-acid catalysts for the asymmetric, oxidative functionalization of alkenes has been developed. In total, eleven different chiral dihydrodiselenocine and (di-)alkoxyphenyl (di)selenide motifs have been synthesized in a concise, modal, and straightforward fashion. Commercially available, non-racemic alcohols have been predominantly used as chiral building blocks for the facile assembly of the selenium-π-acid catalysts. These species have been exemplarily applied to the enantioselective intermolecular imidation and intramolecular acyloxylation of two olefins using N-fluorobenzenesulfonimide (NFSI) and ambient air, respectively, as terminal oxidants. In part, the catalysts provide very good yields of up to 99% and enantiomeric ratios of up to 83.5:16.5 under aerobic conditions. Full article
(This article belongs to the Special Issue Chalcogens in Catalysis: Synthesis and Biology)
Figures

Scheme 1

Open AccessArticle
The Influence of O/S Exchange on the Biocatalytical Activity of Benzisoselenazol-3(2H)-ones
Catalysts 2018, 8(11), 493; https://doi.org/10.3390/catal8110493
Received: 8 October 2018 / Revised: 19 October 2018 / Accepted: 22 October 2018 / Published: 25 October 2018
PDF Full-text (1502 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The crucial feature of organoselenium compounds, when considering them as promising drug candidates in cancer therapy, is their unique ability to alter the cellular redox regulations. Organic Se-molecules continue to demonstrate a positive therapeutic effect both in cancer prevention—as antioxidants, and treatment—as prooxidants. [...] Read more.
The crucial feature of organoselenium compounds, when considering them as promising drug candidates in cancer therapy, is their unique ability to alter the cellular redox regulations. Organic Se-molecules continue to demonstrate a positive therapeutic effect both in cancer prevention—as antioxidants, and treatment—as prooxidants. The growing interest in this field of research highlights the need to search for particular pharmacophore motifs, which could enhance the efficiency and selectivity, and decrease the toxicity of potential anticancer agents. Herein, a series of redox-active organoselenium derivatives—N-functionalized benzisoselenazol-3(2H)-thiones, has been designed and synthetized. A new synthetic pathway, with the application of Lawesson’s reagent, has been developed and efficiently applied. The key steps involving microwave irradiation facilitated performing the reaction in solvent-free conditions, shortening the reaction time and significantly improving the overall yield of the process. Six N-alkyl derivatives have been obtained and tested as antioxidant catalysts and anti-proliferative agents. The N-propyl benzisoselenazol-3(2H)-thione was the best peroxide scavenger and the N-cyclohexyl derivative exhibited the best cytotoxic activity towards prostate cancer cell line DU145. Full article
(This article belongs to the Special Issue Chalcogens in Catalysis: Synthesis and Biology)
Figures

Graphical abstract

Catalysts EISSN 2073-4344 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top