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Research Progress of Ribosome Biogenesis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 December 2023) | Viewed by 7661

Special Issue Editor

Special Issue Information

Dear Colleagues,

Ribosomes are universal biological machines that perform the translation of the genetic code and protein synthesis. Ribosomes are very complex, both structurally and functionally, and their formation requires numerous auxiliary proteins and ncRNA that are not part of the final ribosome. Furthermore, many aspects are evolutionarily conserved, but there are also significant differences between the various domains. This volume aims to produce a rich collection of papers, including original research, in-depth reviews and theoretical analyses, that advance our understanding of ribosome biogenesis, its integration into overall cell physiology and its importance for cell fate.

Prof. Dr. Lasse Lindahl
Guest Editor

Manuscript Submission Information

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Keywords

  • ribosome biogenesis
  • ribosome assembly factors
  • regulation of ribosome synthesis
  • ribosome heterogeneity
  • ribosome synthesis interaction with organism development
  • ribosome synthesis during adaptation to growth conditions and stress
  • ribosome synthesis and translation regulation

Published Papers (2 papers)

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Review

23 pages, 5251 KiB  
Review
Ribosome Specialization in Protozoa Parasites
by Cristian Camilo Rodríguez-Almonacid, Morgana K. Kellogg, Andrey L. Karamyshev and Zemfira N. Karamysheva
Int. J. Mol. Sci. 2023, 24(8), 7484; https://doi.org/10.3390/ijms24087484 - 19 Apr 2023
Cited by 1 | Viewed by 2481
Abstract
Ribosomes, in general, are viewed as constitutive macromolecular machines where protein synthesis takes place; however, this view has been recently challenged, supporting the hypothesis of ribosome specialization and opening a completely new field of research. Recent studies have demonstrated that ribosomes are heterogenous [...] Read more.
Ribosomes, in general, are viewed as constitutive macromolecular machines where protein synthesis takes place; however, this view has been recently challenged, supporting the hypothesis of ribosome specialization and opening a completely new field of research. Recent studies have demonstrated that ribosomes are heterogenous in their nature and can provide another layer of gene expression control by regulating translation. Heterogeneities in ribosomal RNA and ribosomal proteins that compose them favor the selective translation of different sub-pools of mRNAs and functional specialization. In recent years, the heterogeneity and specialization of ribosomes have been widely reported in different eukaryotic study models; however, few reports on this topic have been made on protozoa and even less on protozoa parasites of medical importance. This review analyzes heterogeneities of ribosomes in protozoa parasites highlighting the specialization in their functions and their importance in parasitism, in the transition between stages in their life cycle, in the change of host and in response to environmental conditions. Full article
(This article belongs to the Special Issue Research Progress of Ribosome Biogenesis)
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28 pages, 4690 KiB  
Review
Specialized Ribosomes in Health and Disease
by Sarah C. Miller, Clinton C. MacDonald, Morgana K. Kellogg, Zemfira N. Karamysheva and Andrey L. Karamyshev
Int. J. Mol. Sci. 2023, 24(7), 6334; https://doi.org/10.3390/ijms24076334 - 28 Mar 2023
Cited by 9 | Viewed by 4674
Abstract
Ribosomal heterogeneity exists within cells and between different cell types, at specific developmental stages, and occurs in response to environmental stimuli. Mounting evidence supports the existence of specialized ribosomes, or specific changes to the ribosome that regulate the translation of a specific group [...] Read more.
Ribosomal heterogeneity exists within cells and between different cell types, at specific developmental stages, and occurs in response to environmental stimuli. Mounting evidence supports the existence of specialized ribosomes, or specific changes to the ribosome that regulate the translation of a specific group of transcripts. These alterations have been shown to affect the affinity of ribosomes for certain mRNAs or change the cotranslational folding of nascent polypeptides at the exit tunnel. The identification of specialized ribosomes requires evidence of the incorporation of different ribosomal proteins or of modifications to rRNA and/or protein that lead(s) to physiologically relevant changes in translation. In this review, we summarize ribosomal heterogeneity and specialization in mammals and discuss their relevance to several human diseases. Full article
(This article belongs to the Special Issue Research Progress of Ribosome Biogenesis)
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