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Gut Microbiota Modulation for Health

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (28 May 2024) | Viewed by 1727

Special Issue Editor

Faculty of Veterinary Medicine, Lusófona University, 1749-024 Lisbon, Portugal
Interests: microbiome; microbiology; veterinary medicine; food safety; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

During past decades, the gut microbiota has emerged as a determining factor in health, both for humans and animals. Dysbiosis can change our health status and is in fact a trigger for a wide range of diseases, including cancer, cardio-metabolic diseases, allergies, infections, and obesity. On the other hand, healthy microbiota can help in preventing diseases, and it is becoming increasingly clear that microbiota also influence successful outcomes in medical treatments.

It is, therefore, unsurprising that attempts to positively modulate the microbiome are constantly being pursued, and this area has become a novel and promising field of research. On this matter, bioactive compounds in foods could be of great potential, particularly to the gut microbiota, where it stands out as a crucial moderator in interactions between food and our body. Indeed, an increasing body of evidence suggests that, in future, we will be able to use and explore food and bioactive compounds to modulate the gut microbiota in a way that promotes health, prevents disease, or even assists medical treatments, both in animal and human diseases.

Under this context, the purpose of this Special Issue is to gather the most recent discoveries related to food bioactive compounds that can modulate the microbiome and show their promising potential for human and veterinary medicines.

It is our goal to improve our understanding of the interrelationship between disease, microbiota, and the effects of food bioactive compounds, particularly those that can be used in dietary approaches. We will accept works that encompass (but are not restricted to) different types of bioactive molecules from foods (proteins, peptides, phenolics, sugars, etc.), food additives, and different metabolites. The evaluation of food processes that may alter/enhance activities, the effect of digestion on these compounds, or even the food microbiota itself will be considered as well. Original research papers, reviews, commentaries, and opinion papers are all welcome, both in the areas of human or veterinary medicine.

Dr. Ana Lima
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • microbiota
  • bioactive compounds
  • disease
  • diet

Published Papers (2 papers)

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Review

21 pages, 2042 KiB  
Review
Gut Microbiota Signatures in Colorectal Cancer as a Potential Diagnostic Biomarker in the Future: A Systematic Review
by Lucian-Flavius Herlo, Andreea Salcudean, Roxana Sirli, Stela Iurciuc, Alexandra Herlo, Andreea Nelson-Twakor, Luana Alexandrescu and Raluca Dumache
Int. J. Mol. Sci. 2024, 25(14), 7937; https://doi.org/10.3390/ijms25147937 - 20 Jul 2024
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Abstract
The gut microbiota has acquired significant attention in recent years for its potential as a diagnostic biomarker for colorectal cancer (CRC). In this literature review, we looked at the studies exploring alterations in gut microbiota composition associated with CRC, the potential mechanisms linking [...] Read more.
The gut microbiota has acquired significant attention in recent years for its potential as a diagnostic biomarker for colorectal cancer (CRC). In this literature review, we looked at the studies exploring alterations in gut microbiota composition associated with CRC, the potential mechanisms linking gut dysbiosis to CRC development, and the diagnostic approaches utilizing gut microbiota analysis. Our research has led to the conclusion that individuals with CRC often display alterations in their gut microbiota composition compared to healthy individuals. These alterations can include changes in the diversity, abundance, and type of bacteria present in the gut. While the use of gut microbiota as a diagnostic biomarker for CRC holds promise, further research is needed to validate its effectiveness and standardize testing protocols. Additionally, considerations such as variability in the microbiota composition among individuals and potential factors must be addressed before microbiota-based tests can be widely implemented in clinical practice. Full article
(This article belongs to the Special Issue Gut Microbiota Modulation for Health)
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17 pages, 1059 KiB  
Review
The Role of the Microbiota in the Pathogenesis and Treatment of Atopic Dermatitis—A Literature Review
by Martyna Wrześniewska, Julia Wołoszczak, Gabriela Świrkosz, Hubert Szyller and Krzysztof Gomułka
Int. J. Mol. Sci. 2024, 25(12), 6539; https://doi.org/10.3390/ijms25126539 - 13 Jun 2024
Viewed by 759
Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin condition with a high prevalence worldwide. AD pathogenesis is complex and consists of immune system dysregulation and impaired skin barrier, influenced by genetic and environmental factors. The purpose of the review is to show the [...] Read more.
Atopic dermatitis (AD) is a chronic inflammatory skin condition with a high prevalence worldwide. AD pathogenesis is complex and consists of immune system dysregulation and impaired skin barrier, influenced by genetic and environmental factors. The purpose of the review is to show the complex interplay between atopic dermatitis and the microbiota. Human microbiota plays an important role in AD pathogenesis and the course of the disease. Dysbiosis is an important factor contributing to the development of atopic diseases, including atopic dermatitis. The gut microbiota can influence the composition of the skin microbiota, strengthening the skin barrier and regulating the immune response via the involvement of bacterial metabolites, particularly short-chain fatty acids, in signaling pathways of the gut–skin axis. AD can be modulated by antibiotic intake, dietary adjustments, hygiene, and living conditions. One of the promising strategies for modulating the course of AD is probiotics. This review offers a summary of how the microbiota influences the development and treatment of AD, highlighting aspects that warrant additional investigation. Full article
(This article belongs to the Special Issue Gut Microbiota Modulation for Health)
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